KNOWLEDGE AND UNDERSTANDING
The main objective of the course is to provide the student with the tools necessary for an advanced understanding of the organization and regulation of the human nuclear and mitochondrial genome at the molecular level. The first part of the course is dedicated to providing updated knowledge on the basic characteristics of the human genome and on the potential applications of this knowledge in particular in the biomedical field (eg: pharmacogenetics, gene therapy). The course also aims to provide an overview of the various aspects of mutagenesis with particular reference to the genotoxic risk of environmental origin in humans. Students are provided with basic knowledge on the mechanisms of maintenance, transmission and expression of genetic information, essential for understanding the effects and mechanisms of action of the main genotoxic agents
APPLYING KNOWLEDGE AND UNDERSTANDING
The educational objective consists in obtaining the necessary knowledge for a critical analysis of the organization and regulation of the human nuclear and mitochondrial genome at the molecular level. The topics covered during the lectures are also addressed through the analysis of scientific articles, this activity which involves the active collaboration of the students is aimed at increasing the skills of critical analysis of the students. At the end of the course students will have acquired the necessary skills to face the experimental study of human genetics at the molecular level and of the mutability induced by exposure to genotoxic agents.
The course is aimed at increasing the ability to critically analyze the most current knowledge concerning the complex organization and regulation of the human nuclear and mitochondrial genome at the molecular level.
The articulation of the course includes classroom discussion activities aimed at developing students' aptitude to use the scientific skills acquired to support their arguments.
The critical analysis of scientific articles both during the lessons and during the oral exam, allows the student to develop communication skills both in a group context and at an individual level.
LIFELONG LEARNING SKILLS
The continuous evolution of scientific research and in particular in the field of molecular human genetics require a continuous updating of skills. For this reason, the course aims to provide the necessary autonomy for the achievement of a broader knowledge and for the alignment of skills to the progress of research both in the field of molecular human genetics and genotoxicity.