Learning objectives
(See individual course for a in depth description)
Prerequisites
Basic knowledge of cytology and histology, of general and organic chemistry
Course unit content
1) EXPERIMENTAL MODELS FOR ARTICULAR CARTILAGE REPAIR.
The main content of the Course is "In vitro experimental models for studying the repair of articular cartilage after mechanical and inflammatory injury. Molecular and cellular aspects of chondrogenesis, mechanisms of degenerative pathology and reparative response of the tissue are explained, focusing on "in vitro" models of biocompatibility, biomaterials and biotechnological applications aimed at the cartilage regeneration.
2) EXPERIMENTAL MODELS IN TRANSLATIONAL REGENERATIVE MEDICINE
The first part of the course focuses on deepening the knowledge of the locomotor apparatus, including aspects of embryonic development, morphological and biodynamic characteristics and highlighting the particularities of species. It then covers the classification and treatment of biomaterials used in orthopaedics and dentistry, analysing their historical development and refinement, focusing on biotechnological strategies for the production of biomimetic materials, capable of biochemical interaction with cells and tissues. Molecular and morphological aspects of bone tissue are then explored, and various in vivo and in vitro experimental models are analysed to assess colonisation, osteogenic response, osseointegration and resorption. In addition, concepts of experimental modelling, tissue engineering, replacement medicine, regenerative medicine and nanomedicine applied not only to bone but also to other target organs will be described.
(See individual course for further details)
3) MEDICINAL PRODUCTS FOR ADVANCED THERAPY
Chemistry of natural and synthetic polymers used in biomedical applications, in particular for the production of tridimensional biocompatible systems.The course provides also theoretical knowledge on drug release mechanisms of biologically active substances from polymeric matrices.
Full programme
(See individual course for a in depth description)
Bibliography
Slides of the lectures in pdf and RECORDED LESSONS (E-LEARNING)e; 2) Summary and schematic Lecture Notes on the topics covered; 3) Experimental protocols describing the laboratory practice.4) Scientific reviews from international bibliography.
The educational material is available online (Elly: (https://elly.medicina.unipr.it).
(see individual courses for any other specific topics and for recommended textbooks for study or for further information during exam preparation)
Teaching methods
The course will be held through lectures to Students by slide presentations, which will be available to students on the Elly platform (https://elly.medicina.unipr.it).
The frontal lessons (35 hours) are organized by means of the presentation of the arguments with Power Point slides. Laboratory work (12 hours) will be carried out in the laboratory with the availability of multi-seat microbiological hoods, with thermostated bath for enzymatic isolation of the tissue and inverted optical microscopes for counting and observation of the cells and their culturing in different systems. Students will work directly following laboratory protocols defined for the preparation of primary cultures and of specific culture systems for articular chondrocyte.
For other practicals , various spaces in the Department of Veterinary Medical Sciences will be used, such as the septic room, the veterinary anatomical museum, the histology laboratory and the microscopy laboratory.
Assessment methods and criteria
Oral examination in presence.by means of questions concerning the programme and reference scientific pubblications of the specific modules.
It will be evaluated whether the student has achieved the objective of knowledge and comprehension of the contents and the ability to apply the acquired knowledge (D1,D2).
In formulating the answers, the student will demonstrate property of language and ability to reason by linking together the various topics presented during the course (D3,D4). The examination result is the mediated evaluation of the student's answers to each proposed questions.
The exams will be held in the official sessions.
Passing the exam and final assessment will be the result of the integration of the individual assessments of the teachers in the assessment for the specific modules.
For the module of Experimental models in articular cartilage repair, it 's optional to sustain an ongoing testing (written test multiple choice or Power Point presentation of specific subject with one or more oral questions) on the first part of the program; the examination will be completed, in the date of the official exams, on the topics of the second part and of the practical part with the definition of the final vote.
Students with SLD / BSE must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/le-eli-che-supporto-studenti-con-disabilita-dsa-bes)
Other information
The teacher is available for educational meetings for students in order to further explanations and clarifications, both during the course and for the exam prior agreements via-email.
2030 agenda goals for sustainable development
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