Learning objectives
Considering the significant development and relevance of the structural biology, this course is designed to give students the bases to learn and understand the principles and practise of the most important methods to determine the structure, the conformational stability and dynamics of biomolecules in solution. Attending the course, that is based on theoretical lectures and laboratory practicals, will allow the students to verify their learning skills.
Prerequisites
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Course unit content
Forces that determine biomolecular structure. Structure and dynamics of proteins.
Basic principles of spectroscopy. Electromagnetic waves polarization. Interaction of radiation with matter.
Circular dichroism spectroscopy (CD): basic principles and application to the study of biomolecules.
Nuclear Magnetic Resonance (NMR) spectroscopy: basic principles and applications to the study of structure and dynamics of proteins in solution.
Methods to determine the three dimensional structure of proteins using NMR data.
Main features of Magnetic Resonance Imaging (MRI).
Fluorescence spectroscopy: basic principles and application to biochemical studies.
Laboratory practicals.
Full programme
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Bibliography
All the study materials are provided by the teacher.
Teaching methods
The course will be held through lectures and laboratory practicals to Students either in the classroom (“in presenza”) or in synchronous-streaming (“in telepresenza”) on the Teams platform. Therefore, the opportunity of Student/Teacher interaction will be preserved both face to face and remotely, by the simultaneous use of the Teams platform.
Lectures will be supported by slide presentations, which will be available to students on the Elly platform (https://elly2020.medicina.unipr.it/).
Assessment methods and criteria
The level of achievement of learning objectives will be evaluated by a written exam, consisting of open questions. The knowledge and understanding of the contents by the students will be assessed through questions on the topics included in the whole course.
In case of the persistence of the health emergency, the exams will be conducted remotely, as follows: structured written test conducted remotely (by Teams or Elly).
Students with S.L.D. / B.S.E. must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/le-eli-che-supporto-studenti-con-disabilita-dsa-bes
Other information
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