cod. 06030

Academic year 2022/23
1° year of course - Second semester
- Ovidio BUSSOLATI - Martina CHIU
Academic discipline
Patologia generale (MED/04)
Attività formative affini o integrative
Type of training activity
24 hours
of face-to-face activities
3 credits
hub: -
course unit


Learning objectives

The student will acquire specific notions on the pathogenetic role of nutritional factors in human pathology, understanding alterations at cell, tissue and organism levels. Moreover, she/he will be able to understand the molecular and cellular bases of the main nutritional disorders and to evaluate causes, mechanisms and consequences of uncorrect nutritional habits.


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Course unit content

Fundamentals in cell pathology. Pathophysiology of nutrition: nutritional deficiency and nutritional excess.
Food allergy and intolerance.
Nutrition and cancer.

Full programme

1. Fundamentals in cell pathology:
- Cell injury
- Major types of cell stress: oxidative, ER, ischemic, nutritional
- Cell death
- An introduction to inflammatory response
- Storage disease: steatosis

2. Pathophysiology of nutrition:
-Hypo- and hypervitaminosis
- Trace elements deficiences
- Pathophysiology of obesity
- Role of obesity in chronic multifactorial diseases

3. Food allergy and intolerance:
- Fundamentals in immunology
- Immune tolerance
- Hypersensitivity
- Food allergies and anaphylaxis
- Food intolerance
- Cellular bases of celiac disease

4. Food and cancer:
- General concepts in oncology
- Cancer hallmarks and cancer progression
- Molecular bases of cancer: protooncogenes and oncosuppressors
- Chemical cancerogenesis
- Food constituents and cancer
- Diet and cancer
- Cachexia


Students should use as a reference one of the modern textbooks of general pathology:
1. Kumar, Abbas, Fausto, Aster (Eds). Robbins e Cotran – Le Basi
Patologiche delle Malattie. 10 Edizione italiana, Elsevier Masson, 2021.

2. Mainiero, Misasi, Sorice (Eds.) Patologia Generale e Fisiopatologia
2 vol. VI edizione
Piccin, 2019.

3. Altucci, Berton, Moncharmont, Stivala (Eds.)
Patologia e Fisiopatologia Generale, 2 vol.
Ildeson-Gnocchi, 2018

Additional references will be suggested during the lectures.

Teaching methods

Lessons will be on site in compliance with safety standards, provided that further instructions on the ongoing health emergency are not implemented.
Lectures will be interactive and will be carried on through a dialogue between the teacher and the students. Examples of true-life situations and clinical cases will be also provided so as to raise the interest of the students.
Supporting didactic material will be available on the specific, student-restricted platform (Elly) and will include slide presentations and audio-video aids.
Slide consultation will be necessary but NOT sufficient for students preparation.

Assessment methods and criteria

Oral examination concerning the whole Course. One of the questions will concern one of the subjects enlisted in the extended program. For additional information, see the Syllabus of the Course.

Other information

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