MOLECULAR BASES OF DRUG ACTION
cod. 1005046

Academic year 2022/23
2° year of course - First semester
Professor
Gabriele COSTANTINO
Academic discipline
Chimica farmaceutica (CHIM/08)
Field
Discipline farmaceutiche
Type of training activity
Characterising
42 hours
of face-to-face activities
6 credits
hub: PARMA
course unit
in ITALIAN

Integrated course unit module: DRUGS AND MEDICINES

Learning objectives

Through class attendance and through self-study, the student will acquire the following skills

Knowledge and understanding: The student will demonstrate knowledge of the physico-chemical bases that regulate the operation of nuclear receptors and membrane; to understand the mechanisms through which small molecules activate or block nuclear or membrane receptors

Applying knowledge and understanding: The student must show to be able to synthesize their knowledge, their ability to analyze and understand the structure-activity relationships for classes of drugs through devising and sustaining critical arguments in the field of medicinal chemistry, proving to be able to have a professional approach to discipline

In addition, the teaching aims to achieve autonomy of judgment and Communicative Abilities.

Making judgments: Students will be able during the lessons, to interact with the themes suggested by the teacher and, even with the help of the recommended texts and teaching materials, be able to make independent judgments

Communication skills: The student must be able to clearly and critically present the results of their individual calculations, demonstrating knowledge of research topics carried out during the program

Prerequisites

Organic Chemistry , Medicinal Chemistry , Biochemistry , Physiology , Pharmacology

Course unit content

1 ) Drugs and drug targets : An Overview
- What is a drug ?
- Drug targets
- Forces of intermolecular bonds

2 ) Receptors : structure and function

3 ) enzymes as drug targets

4 ) receptors as drug targets

5 ) Absorption of Drugs

6 ) Distribution of drugs

7 ) Drug Metabolism

8 ) Elimination of drugs

9 ) Antibacterial Agents

10 ) cholinergic drugs , anticholinergics, and anticholinesterases

11 ) Antipsychotic drugs

12 ) Drugs anti - Parkinson

13 ) Drugs for anxiety disorders , sedatives , hypnotics

14 ) Opioid analgesics

Full programme

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Bibliography

Graham L. Patrick ,
Pharmaceutical Chemicals,
III edition , EdiSES

Teaching methods

The course will be conducted through lectures . Each lesson is a teaching module unit , in which , for each topic , are given to the student the foundation for acquiring knowledge and understanding , and to apply the knowledge and understanding to the problem treated in the unit of learning module

Assessment methods and criteria

Through an oral exam it will be ' verified that the student has successfully acquired the knowledge and understanding and the ability to apply knowledge and understanding of at least three topics covered in the course . In addition , it will be ' evaluated the independence of judgment and communication skills . The examination is only passed if the student will demonstrate a correct acquisition of skills . The vote will be formed for 30% of knowledge and understanding , 30 % of application of knowledge and understanding , 20 % of independent judgment and 20 % of communication skills .

Other information

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2030 agenda goals for sustainable development

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