BIOTECHNOLOGY | University of Parma

Professor: Tiziana LODI
Academic discipline: Genetica (BIO/18)
Field: Discipline biotecnologiche comuni
Type of training activity: Characterising

76 hours
of face-to-face activities

9 credits

hub: PARMA

course unit
in ITALIAN

lectures timetable unavailable

exam calls

Learning objectives

To provide the first year students with the basic concepts of classical and molecular genetics

Prerequisites

None

Course unit content

The cours is composed of two main sections. 1.CLASSICAL GENETICS: Mitosis and meiosis. Mendelian genetics. Independent assortment and genetic characters segregation. Modification of mendelian ratios: Co-dominance, Multiple alleles, Lethal alleles, Gene interaction. X-linked genes. Chromosome theory of inheritance. Linkage and recombination. Crossing over. Recombination in yeast (tetrads analysis). Mechanisms of genetic recombination in prokaryotes: bacterial transformation, bacterial conjugation, transduction
2. MOLECULAR BASIS OF HEREDITY: Experiments leading to the discovery of DNA as genetic material. DNA: structure and replcation. Chromosome structure in prokaryotes and eukaryotes. RNA structure, transcription and translation. The genetic code and its deciphering. Gene structure and organisation. Interrupted genes. The one-gene: one-enzyme hypothesis. Dissection of biochemical pathways. Genetic complementation. Gene expression. Genome, chromosomes and gene mutations. Molecular basis of the mutation. Reversion. Suppression. Detection of spontaneous or induced mutants. Regulation of gene expression in prokaryotes. Operon Lac: negative and positive control. Operon TRP. Retroinibition
Practical and theoric activities are supporting the lessons.

Full programme

1.CLASSICAL GENETICS: Mitosis and meiosis. Mendelian genetics. Independent assortment and genetic characters segregation. Modification of mendelian ratios: Co-dominance, Multiple alleles, Lethal alleles, Gene interaction. X-linked genes. Chromosome theory of inheritance. Linkage and recombination. Crossing over. Recombination in yeast (tetrads analysis). Mechanisms of genetic recombination in prokaryotes: bacterial transformation, bacterial conjugation, transduction
2. MOLECULAR BASIS OF HEREDITY: Experiments leading to the discovery of DNA as genetic material. DNA: structure and replcation. Chromosome structure in prokaryotes and eukaryotes. RNA structure, transcription and translation. The genetic code and its deciphering. Gene structure and organisation. Interrupted genes. The one-gene: one-enzyme hypothesis. Dissection of biochemical pathways. Genetic complementation. Gene expression. Genome, chromosomes and gene mutations. Molecular basis of the mutation. Reversion. Suppression. Detection of spontaneous or induced mutants. Regulation of gene expression in prokaryotes. Operon Lac: negative and positive control. Operon TRP. Retroinibition
Practical and theoric activities are supporting the lessons.

Bibliography

Snustad DP, Simmons MJ (2014)
Principi di Genetica
5a Edizione
EdiSES

Binelli, Ghisotti (2018)
Genetica
EdiSES

Griffiths AJF, Wessler SR, Carroll SB, Doebley J (2013)
Genetica
7a Edizione
Zanichelli Ed

Teaching methods

Frontal lectures and exercises; laboratory activities

Assessment methods and criteria

Written and oral examen

Other information

- - -

2030 agenda goals for sustainable development

- - -

Contacts

Toll-free number

800 904 084

Student registry office

T. +39 0521 905116
E. segreteria.scienze@unipr.it

Quality assurance office

Education manager
Elisabetta Davolio Marani
T. +39 0521 905613
Office E. didattica.scvsa@unipr
Manager E. elisabetta.davoliomarani@unipr.it

Course President

Prof Mariolina Gulli'
E. mariolina.gulli@unipr.it

Faculty advisor

Prof Giovanna Visioli
E. giovanna.visioli@unipr.it
Prof Benedetta Passeri
E. benedetta.passeri@unipr.it

Career guidance delegate

Prof Paola Goffrini
E. paola.goffrini@unipr.it

Erasmus delegates

Prof Elena Maestri
E. elena.maestri@unipr.it

Quality assurance manager

Prof. Mario Veneziani
E. mario.veneziani@unipr.it

Internships

Prof. Mariolina Gullì
E. mariolina.gulli@unipr.it

Tutor students

Ms Beatrice Giardina
E. beatrice.giardina@studenti.unipr.it

Ms Sophia Luche
E. sophia.luche@unipr.it

GENETICS AND INTEGRATED BIOTECHNOLOGIES LABORATORY I cod. 1000863