SYSTEM BIOLOGY
cod. 1005238

Academic year 2021/22
3° year of course - First semester
Professors
Academic discipline
Biologia applicata (BIO/13)
Field
Attività formative affini o integrative
Type of training activity
Related/supplementary
48 hours
of face-to-face activities
6 credits
hub: PARMA
course unit
in ITALIAN

Learning objectives

The objective of the course is to provide to students the general principles of System Biology, elucidating them with examples taken from Biotechnology, and providing instruments to understand the literature in the field.
At the end of the course the student will be able to:
• Describe the main omics techniques described in the course
• Describe biological network
• Use the main databases and web services available on-line
• Read, describe and discuss scientific articles on topics described in class

Prerequisites

Some previous knowledge of general biology, molecular biology and genetics is highly advisable, as well A a suitable level of English to read references in the language.

Course unit content

System Biology is the systematic and quantitative investigation of cell functions, cells and organisms, spanning the link between molecular biology and physiology. It is based on knowledge of molecular, chemical and physical processes underlying these functions, integrated with a modellinstic mathematical approach. System Biology stems from the new methods for experimental analysis, based on the sequencing of whole genomes and on high-throughput analytical methodologies (genomics, transcriptomics). System Biology sees the cell as a "chemical factory" in which substances from outside are processed to provide energy and materials, in sophisticated processes performed by specialised molecules encoded by the DNA.

Full programme

The topics will include:
-General concepts on networks, systems, graphs
-Properties of the networks
-Molecular techniques in the study of biological systems (omics): DNA, RNA, proteins, metabolites
-Databases and web services for creating networks
-Case studies

Bibliography

The study material is provided by the teacher and available partially as a booklet and on Elly. It will be based on papers from the international literature and on slides shown during the lectures. Textbooks will be suggested if needed.

Teaching methods

Face to face lectures in the classroom, practical demonstrations of databases and web services, analysis of case studies

Assessment methods and criteria

Oral exam, including an in depth study on a topic selected according to instruztions from the lecturers.
The exam will assess the acquisition of competence, the capacity to apply knowledge, authonomy in the choice of the topic, and communication ability.

Other information

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