Learning objectives
the student should possess basic notions on the pathophysiology of the hematopoietic system and of the oncogenetic and infective process. The knowledge of conventional and innovative diagnostic and therapeutic strategies is also required. Moreover, the student should achieve the principles of stem cell therapy to treat hemato-oncologic diseases.
Prerequisites
- - -
Course unit content
basic knowledge on hematopoietic function and major hemathologic diseases
Full programme
Pathophysiology of the hematopoietic system
Stem cells and bone marrow transplantation
The student should aquire the basic knowledge on the pathogenesis of following conditions:
Anemias, thrombocytopenias, neutropenia;
Myelodysplastic syndromes;
Acute Leukemias;
Myeloproliferative diseases;
Monoclonal gammopathies and Multiple Myeloma;
bone marrow transplantation;
conventional and targeted anticancer therapy;
roles and functions of oncoproteins;
MAPK, AKT, STAT3, p53, p73, NF-kB PML and c-Abl signaling pathways;
cell cicle; Apoptosis; necrosis; myeloid differentiation;additive synergistic antagonistic pharmacological interactions between two or more drugs
Bibliography
1) Slides of the lectures; 2) Scientific papers from international bibliography.
Teaching methods
lectures with slide show; laboratory exercises.
Assessment methods and criteria
oral test
Other information
All the slides presented during the formal lessons and laboratory exercises will be available.
