DESIGN OF BIOTECHNOLOGICAL VACCINES
cod. 1000267

Academic year 2016/17
1° year of course - Second semester
Professor
Academic discipline
Microbiologia e microbiologia clinica (MED/07)
Field
Discipline biotecnologiche comuni
Type of training activity
Characterising
42 hours
of face-to-face activities
6 credits
hub: PARMA
course unit
in - - -

Learning objectives

The objectives of the course are to enable the acquisition of knowledge and understanding about anti-infective vaccinology, relevant existing vaccines, biotechnological vaccines (characteristics and development), existing biotechnological tools in vaccinology, main viral vectors for gene therapy and immunotherapy, and provide the ability to apply in occupational contexts the knowledge and understanding acquired.

Prerequisites

No

Course unit content

Principles and immunological basis of vaccinology. Relevant available anti-infective(live-attenuated, killed-inactivated, subunit, purified or conjugated antigens, toxoids, recombinant) or experimental vaccines (DNA, anti-idiotypic). Biotechnological vaccines and their design: characteristics and development. Existing biotechnological vaccines
(HBV, HPV, Rotavirus, polysaccharide-conjugated vaccines). Rational design. Reverse vaccinology. Recombinant bacteriophges and bacteria as vaccines and vaccine delivery veicles. Plant-based vaccines. Adjuvants and delivery systems. Viral vectors for gene therapy and immunotherapy. Retrovirus: Molecular aspects of viral replication. Architecture of following viral vectors: Oncoretrovirus (MMLV) and Lentivirus. Packaging strategies and mechanism of targeting and peseudotypization (VSV-G). Cellular transduction and expression control.

Full programme

Principles and immunological basis of vaccinology. Relevant available anti-infective (live-attenuated, killed-inactivated, subunit, purified or conjugated antigens, toxoids, recombinant) or experimental vaccines (DNA, anti-idiotypic). Biotechnological vaccines and their design: characteristics and development. Existing biotechnological vaccines (HBV, HPV, Rotavirus, polysaccharide-conjugated vaccines). Rational design. Reverse vaccinology. Recombinant bacteriophges and bacteria as vaccines and vaccine delivery veicles. Plant-based vaccines. Adjuvants and delivery systems. Viral vectors for gene therapy and immunotherapy. Retrovirus: Molecular aspects of viral replication. Architecture of following viral vectors: Oncoretrovirus (MMLV) and Lentivirus. Packaging strategies and mechanism of targeting and peseudotypization (VSV-G). Cellular transduction and expression control.

Bibliography

Iconographic material used during lectures.
Reviews on specific topics.
References on specific subjects provided during lectures.

Teaching methods

The arguments regarding the course content will be presented and discussed through lectures, with the aid of iconographic material collected in PowerPoint files that, at the end of the course, will be made available to students. Lectures will present the main conceptual frame of each subject, summoning questions or doubts from the audience.

Assessment methods and criteria

The outcomes of learning will be verified through an oral examination. Questions on the topics relating to the course will be used to test the knowledge and understanding of the student in the scientific discipline, in order to apply such knowledge and understanding in occupational contexts.

Other information

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