The target of this course is to lead the student to basic knowledge and understanding of the structure and function relationship among biological macromolecules and of the energetic metabolism of euchariotic cells and animal tissues. A particular interest will be devoted to the understanding of energy production, utilization and storing in order to sollicit students to apply their knowledge on questions typically of today’s interest such as the basal metabolism of living organisms and some physiologycal functions such as (hormone regulations of metabolism, the mechanism of muscular contraction, etc.). Matter of great interest is also the energetic metabolism in relation with oxygen utilization. Moreover, a large part of lessons will be devoted to the issue of oxygen deprivation in different animal systems and living conditions. At the end of this course and with the knowledge acquired by other course as physics, anatomy and general and organic chemistry, the student should demonstrate by means of his learning skills, the ability of making judgements, communication skills, which is the termodynamic impact that the energetic need of living systems may exert on our ecosystem.