Medical, veterinary anf pharmaceutical biotechnologies

Professor
Academic discipline: Farmaceutico tecnologico applicativo (CHIM/09)
Field: Attività formative affini o integrative
Type of training activity: Related/supplementary

14 hours
of face-to-face activities

2 credits

hub: -

course unit
in - - -

lectures timetable unavailable

exam calls

Integrated course unit module: BIOMATERIALS AND BIOCOMPATIBLE SYNTHETIC MATERIALS

Learning objectives

The main goal of the course is the understanding of the chemistry and physics of natural and sinthetic polymers used in tissue engineering and drug delivery.

Prerequisites

General knowledge of inorganic and organic chemistry are required

Course unit content

Chemistry of natural and synthetic polymers used in biomedical applications, in particular for the production of tridimensional biocompatible systems.
The course provides also theoretical knowledge on drug release mechanisms of biologically active substances from polymeric matrices.

Full programme

• Polymer definition and classification.
• Linear and crosslinked polymers, method of polymerisation and crosslinking.
• Polymer molecular weight and its determination.
• Solid state of polymers, crystalline and amorphous structure.
• Glassy and rubbery state, transition temperature.
• Polymers in solution.
• Natural and synthetic polymers used in biomedicine.
• Tridimensional structure of polymeric scaffolds.
• Chemical modification of polymers.
• Solid state manipulation.
• Physico-chemical characterisation of tridimesional polymeric structures, and films.
• Polymeric scaffolds as drug delivery systems.
• Drug release kinetics from matrix systems.

Bibliography

A. Martin, Physical Pharmacy, Fourth Edition, Lea & Febiger 1993

Bibliographic material will be distributed during the course

Teaching methods

The course will be carried out through frontal lessons in which the fundamentals of polymer chemistry will be presented and discussed, as well as well as the solid state chemistry and the behaviour in solution.
In the second part of the course the concepts presented in the first one will be applied to the manipulation of the polymers, mostly of natural origin, for the preparation of hydrogels and tridimensional structures for tissue repair.

Assessment methods and criteria

Oral exam consisting in questions aiming at verifying the comprehension of the studied topics and the competences acquired. The results will be expressed in 30th.

Other information

- - -

MEDICINAL PRODUCTS FOR ADVANCED THERAPY cod. 1000255