Learning objectives
Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented. The student will attend practical lessons in cytology in order to be able to recognize normal and activated cells of the immune system.
Prerequisites
none
Course unit content
Inflammatory processes and immune system are in troduced as basic response to injuries. Basis to comprehend the organization, function and regulatory mechanisms of body defences, so important to maintain body health, will be provided. Examples will demonstrate the essential importance of antigen recognition mechanisms for body protection. Basis for comprehension of immune system iperergic reactions, when regulatory mechanisms fail, will be provided. The principals autoimmunitary mechanisms will be presented.
Full programme
The immune system (cells, primary and secondary lynphoid organs), lymphocytes recirculation
Acute inflammation: definition, aetiology, vascular and cellular changes, inflammatory cells and chemokynes, resultsa and consequences.
Chronic inflammation, primary and granulomatous: cellular aspects and mediators, systemic effects
Innate and acquired immunity
Antigens: structure and functions. Antigen-antibody link. Monoclonal antibodies.
B lynphocytes receptor and T lymphocytes receptor: Lymphocytes repertoire formation and clonal selection.
MHC I and II classes: structure and functions. Oesogenous and endocgenous antigen processing. Antigen presenting cells and organs transplantation.
Lymphocytes activation. Primary and secondary response. Immunological memory.
Laboratory methods based on antigen-antibody reactions and adaptative immunity cells.
Immunopathology princeples: hypersensitivities (I, II, III, IV). Tolerance and autoimmunity and pathogenetic mechanisms. Immunodeficiecies and immunodepression. Stress and immune system.
Bibliography
Veterinary Immunology, Tizard I.R., Elsevier 8°edizione(2013)
Pier G., Lyczak J.B., Wetzler L.M., Immunologia Infezione, Immunità, (2006) Piccin
Murphy K, Travers P., Walport M, Janeway's Immunobiologia, (2009) Saunders
McGavin M.D., Zachary J.F., Patologia Generale Veterinaria, (2008) Elsevier
Robbins e Cotran-le basi patologiche delle malattie vol 1 (2010) Elsevier
Teaching methods
theoretical lessons with slides presentation (42 ore)
Assessment methods and criteria
The exam requires submission of an essay concerning 4 subjects explained in the lessons. Verification of Dublin descriptors: -knowledge is included in the essay, since the students describes immunity mechanisms -application of knowledge is included in the essay, since the student can associate the immunity mechanisms to pathology-communication skills are verified by the quality of the essay and compliance with requisites -making judgements is verified in the comprehension of the subject and in the skill to associate it to the different pathology. The exam is taken in about 2 hours
Other information
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