Learning objectives
The aim of the course is to provide student with operative knowledge of bone biology, focused on anabolic and catabolic processes, as they may be involved in designing novel approaches for bone regeneration
Prerequisites
Cell biology, histology
Course unit content
Analysis of cellular and molecular mechanisms underlying bone turnover and metabolism
Full programme
Basics of bone anatomy and histology
Osteoblasts, origin, differentiation and function
Osteoclasts, origin, differentiation and function
Osteocytes, morphology and physiology
Bone remodelling, and its regulation
PTH and PTHrP
Canonical wnt signaling and its function in bone
Mechanical loading and bone
Oxidative stress and bone
Bibliography
International reviews and scientific commentaries will provided by the teacher.
The following chapters will be useful for the course:
Strategies in regenerative medicine (Ed. M. Santin, Springer, 2009, pp. 55-154, 431-466);
Further reading:
Osteology guidelines for Oral and Maxillofacial Regeneration (Quintessence, 2011);
Fundamentals of Tissue Engineering and Regenerative Medicine (Springer, 2009)
Teaching methods
Lectures
Assessment methods and criteria
Written examination, multiple choice test
Other information
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2030 agenda goals for sustainable development
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