Learning objectives
The course aims at providing students with the molecular basis for the
understanding of the interaction between biological macromolecules and ligands,
with a focus on drug targets.
Prerequisites
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Course unit content
PART ONE: RECOMBINANT DRUGS
Expression systems: bacteria, yeast, mammalian cells, plants and transgenic
animals
Recombinant insulin
Edible vaccines
Subunit vaccines: vaccines against HVB and HPV
Recombinant factor VIII
Recombinant Erythropoietin
ATryn (recombinant antithrombin)
Antibodies and their application in therapy
PART TWO: DRUG TARGETS
Definition of drug and drug target
Binding properties of proteins
Enzymatic catalysis
Enzymes as drug target
Reversible inhibitors
Irreversible inhibitors
Enzyme activators
Receptors as drug targets
Transmembrane channels and transporters as drug targets
DNA as a drug target
RNA as a drug target
Full programme
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Bibliography
David L. Nelson, Michael M. Cox
I PRINCIPI DI BIOCHIMICA DI LEHNINGER 5 ed, ZANICHELLI
Teaching methods
LECTURES
Assessment methods and criteria
ORAL EXAM
Other information
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