THE HUMAN MICROBIOME
cod. 1011309

Academic year 2023/24
1° year of course - First semester
Professor
- Leonardo MANCABELLI
Academic discipline
Microbiologia generale (BIO/19)
Field
Attività formative affini o integrative
Type of training activity
Related/supplementary
14 hours
of face-to-face activities
2 credits
hub: -
course unit
in ENGLISH

Learning objectives

The course allows the student to focus on some problems and solutions needed to acquire the knowledge to understand the main phenomena involved in the biological processes of bacteria.
It aims to provide a multidisciplinary (genomic, ecological) approach for an effective understanding of biological and evolutionary processes in the field of applied microbial ecology.
At the end of the course, students are expected to be able to:
i) Know the logic and microbiological aspects of human health and welfare.
ii) Be able to analyze and critically interpret data and statistical products / reports (microbiota studies using 16S rRNA microbial profiling as well as shotgun metagenomics approaches).
iii) Knowing how to communicate the results of a research (in the field and empirical) through the preparation of a research report.
iv) Be able to build and manage relationships with people or groups (aimed at achieving the objectives of the planned work.
v) Knowing how to improve their performance (in terms of resources and results) based on a reference standard that respects well-being, biodiversity and sustainability.

Prerequisites

None

Course unit content

The course aims to familiarize the student with concepts, techniques and specifications related to general and applied microbiology. It provides an understanding of the main phenomena that occur in the world of microorganisms and in their interaction with the human being.

Full programme

Introduction to bacteriology (bacterial cell and extracellular structures)

Interaction of bacteria with the environment

Assessing of the biodiversity of complex microbial communities

Metagenomics approaches to investigate the functionality of the microbiota
The gut microbiota: origin, development and composition.
The human intestinal microbiota: dysbiosis, and correlations with diseases.
The oral, vaginal and skin human microbiota.
Bacterial therapy approaches for the modulation of the human microbiota.

Bibliography

Brock Biology of Microorganisms, Madigan, International Edition, Pearson
Biologia dei Microrganismi, Deho', Galli, CEA

Teaching methods

The course includes lectures with the screening of educational material.

Assessment methods and criteria

The student will be assessed through an oral interview in which the basic concepts (microbial cell structure, microbial determinants responsible for interaction with the host / environment and other microorganisms) will be verified. Once the first phase of the interview has been completed, the student's logical and critical ability in dealing with an animal microbiota study will be verified, evaluating its ability to integrate innovative interventions (on the front of used technologies and biological bases) that go to protect well-being and sustainability.

At the same time terminological correctness, consistency between the student's answer and the question posed, rigor and attention to the logic of the supply chain, demonstration of a multiomics and multidisciplinary systemic approach, demonstration of having acquired those transversal skills so decisive and incisive in professional life.
In exceptional cases and, at the express request of the student himself, the verification in written form is foreseen. With regard to female students and students with specific learning disabilities (with reference to the ministerial decree 12th July 2011) dispensatory measures and compensatory tools will be applied, ie oral tests, use of PCs with spell check and speech synthesis, but above all, will be granted an extra time up to a maximum of 30% more or a quantitative reduction will be provided. In any case, the evaluation logic followed, in these circumstances, will evaluate the contents rather than the form.

Other information

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