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Università degli Studi di Parma Università degli Studi di Parma
Second cycle degree course in
Medical, veterinary anf pharmaceutical biotechnologies
Università degli Studi di Parma
Department of Medicine and Surgery

PHARMACEUTICAL BIOCHEMISTRY
cod. 23806

Academic year 2016/17
1° year of course - First semester
Professor
Barbara CAMPANINI
Academic discipline
Biochimica (BIO/10)
Field
Discipline biotecnologiche comuni
Type of training activity
Characterising
42 hours
of face-to-face activities
6 credits
hub: PARMA
course unit
in - - -
lectures timetable unavailable
exam calls

Integrated course unit module: INTERACTION DRUG-BIOMOLECULES

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Learning objectives

The course aims at providing students with the molecular basis for the
understanding of the interaction between biological macromolecules and ligands, with a focus on drug targets.

Prerequisites

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Course unit content

Definition of drug and drug target
Binding properties of proteins
Enzymes as drug target
Treatment of HIV and NSAIDs as examples of the therapeutic use of enzyme inhibitors
Receptors as drug targets
Recombinant drugs

Full programme

• Drug and drug target: definition

• Binding properties of proteins

• Enzymatic catalysis

• Intracellular receptors

• GPCRs

• Receptor tyrosine kinases

• Tyr kinase-associated receptors

• Receptor guanylyl cyclases

• Enzyme inhibition and rug discovery:
o Enzymes as drug targets
o Reversible inhibitors
o Irreversible inhibitors
o Tight-binding and slow-binding inhibitors
o NSAIDs
o Enzyme inhibition in HIV therapy

• Recombinant drugs:
o General principles for recombinant drugs production
o Recombinant drugs produced in E. coli
o Recombinant drugs produced in yeast
o Recombinant drugs produced in CHO
o Recombinant drugs produced in plant cells
o Recombinant drugs produced in transgenic organisms

Bibliography

Selected scientific papers and copy of slides can be downloaded from the Elly
website.

David L. Nelson, Michael M. Cox
I PRINCIPI DI BIOCHIMICA DI LEHNINGER 5 ed, ZANICHELLI

Copeland R. Evaluation of enzyme inhibition in drug discovery, Wiley.

Teaching methods

The topics of the course will be delivered with oral presentations associated with informatics tools and visits to laboratories

Assessment methods and criteria

The exam is either a written "in itinere" test or a final oral test.
The written test will take place during the teaching semester and will consist of two tests, dealing with the first and second part of the programm, respectively. The teaching module final mark is the average of the marks of the two tests.
The oral test is given together with the test for the Biological Physical Chemistry module during the exam periods.

Other information

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2030 agenda goals for sustainable development

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Contacts

Toll-free number

800 904 084

Segreteria studenti

E. [segreteria.medicina@unipr.it]
T. +39 0521 903700

Servizio per la qualità della didattica

Manager della didattica:
Rag. Sabrina Ferrari
T. +39 0521 903109
E. servizio [didattica.dimec @unipr.it]
 

Presidente del corso di studio

Prof, Nicola Giuliani
E. nicola.giuliani@unipr.it

Delegato orientamento in uscita

Prof.ssa Sara Nicoli
E.sara.nicoli@unipr.it

Delegati Erasmus

Prof. Roberto Sala

E. roberto.sala@unipr.it

Referente assicurazione qualità

Prof.ssa Carlotta Compari
E. carlotta.compari@unipr.it

Tirocini formativi

Prof.ssa Laura Giovati

E. laura.giovati@unipr.it