Learning objectives
The student, taking also in account the knowledge of anatomy, biology, physiology, general pathology and biochemistry already acquired in previous Courses, should demonstrate understanding about:
• generalities on medicines
• the chemistry of radioactive molecules,
• the major pharmaceutical forms and routes of administration of radiopharmaceuticals
• the distribution of radioactive molecules in the body,
• the prototype molecules used in radiodiagnostic and radiotherapy,
• the toxic effects of radionuclides on the body and how to avoid them.
Prerequisites
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Course unit content
The teaching of "Pharmacology and Radioactive drugs" aims to educate the student to the knowledge of the radionuclides used as tracers in diagnostic medicine, and to the understanding of the fundamental principles that govern the movement of these molecules in the body. As a general concept, the student will be encouraged to evaluate the factors that affect the specific accumulation of radioactive tracers in certain districts of the organism, an event underlying the radiodiagnostic and radiotherapeutic use of radioactive molecules, as well as the possible toxic effects of these molecules on the organism.
Full programme
General information about medicines, their classification, dispensing methods, AIC.
Pharmacokinetic: adsorption, distribution, metabolism and excretion.
Pharmacodynamics
Generalities on radiopharmaceuticals: radionuclides, alpha, beta, positron and gamma emitters
SPECT, PET e scintigraphy
Organ-specific compounds: Iodine and iodinated radionuclides, fluorine ()18FDG), Technetium. Radionuclides designed for Central nervous system: markers of the aminergic systems.
Radionuclides and molecules designed for renal and pulmonary scintigraphy.
Radionuclides designed for cardiac scintigraphy
Metabolic therapy and radiotherapy.
Synthesis and preparation of labeled compounds; quality control of radiopharmaceuticals: stability and purity; rules of good laboratory practice.
Legal and liability issues.
Bibliography
Fondamenti di medicina nucleare - Volterrani, Erba, Mariani - Springer
Teaching methods
Classroom lectures
Assessment methods and criteria
Oral examination.
For the determination of the final mark the following descriptors are adopted:
• knowledge and understanding of the subjects (up to 12/30);
• ability to apply the knowledge (up to 10/30);
• ability to communicate the learned knowledge and skills in verbal form through the appropriate use of the techinical language (up to 8/30).
Other information
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