cod. 00111

Academic year 2011/12
2° year of course - First semester
Academic discipline
Chimica organica (CHIM/06)
Attività formative affini o integrative
Type of training activity
48 hours
of face-to-face activities
6 credits
course unit
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Learning objectives

Aim of the course is the study of the main biological pathways that produce secondary metabolites. Their metabolic, physiological and pharmaceutical role will be discussed either in the producing organisms or in the receiving organisms


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Course unit content

<br />Module 1- <br />Energy, work, order; energy preservation and thermodynamic laws; energy fluxes in nature and in systems far from equilibrium. Evolution in biological systems; Prebiotic chemistry, biological homochirality, prokariotes and eukariotes, Catabolism, harvesting the light. Enzymes and coenzymes; role of enzymes and coenzymes in biological catalysis;  vitamines.<br />Module 2- <br />Terpenes; biogenesis of  terpenes, monoterpenes, sesquiterpenes, diterpenes, natural rubber; squalene e phitoene, carotenoids, cicle of vision.<br />Steroids; biogenesis of steroids, squalene, lanosterol, cholesterol; corticosteroids, sexual hormones, bile salts; physiological role.<br />Fatty acids; biogenesis of saturated, monounsaturated, poliunsaturated fatty acis; Biogenesis of prostaglandines, tromboxanes, leukotrienes, lipoxines; physiological role.<br />Acetogenines; biogenesis of acetogenines, flavanoids.<br />Antibiotics; biogenesis and physiological role of the antibiotics; mechanisms of action of  antibiotics.<br />Shikimic acid; biogenesis of the shikimic acid; aromatic ammino acids, tetracyclines.<br />Alcaloids; nomenclature, classification and biological role; biogenesis of selected compounds.

Full programme

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P. M. Dewick, Chemistry, biosyntesis and bioactivity of organic natural substances, Piccin, Padova

Teaching methods

Frontal lectures

Assessment methods and criteria

Oral examination

Other information

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