Pharmacology
cod. 1009730

Academic year 2022/23
2° year of course - Second semester
Professor
POLI Enzo, COSTA Lucio Guido, ADORNI Maria Pia, POTI' Francesco
Academic discipline
Farmacologia (BIO/14)
Field
Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Type of training activity
Characterising
90 hours
of face-to-face activities
9 credits
hub: PIACENZA
course unit
in ENGLISH

Learning objectives

Knowledge and understanding of beneficial and toxic drug effect, aimed to a correct application of medicaments in the clinical setting.

Prerequisites

Knowledge and passing the exams of anatomy, biochemistry, phisiology and general pathology

Course unit content

Pharmacological properties of the different drug classes and their specific use in the clinical setting

Full programme

Pharmacology of autonomic and somatic nervous system: cholinergic and adrenergic transmission.
Cholinergic drugs: direct and indirect agonists; muscarinic antagonists.
Adrenergic system drugs: specific receptor agonists and antagonists.
Central adrenergic stimulants: cocaine, amphetamine or methylphenidate.
Ganglionic stimulant and blockers: nicotine and ganglioplegic drugs
Depolarizing and competitive neuromuscular blocking.
Central nervous system: general and local anesthetics, sedative-hypnotics, anxiolytics, antiepileptics, centrally-acting spasmolytics. Drugs
for Parkinson and other neurodegenerative diseases. Antipsychotics and antidepressants.
Opioid and non-opioid analgesics. Compounds of abuse.
Chemotherapy: General definition, mechanisms of action, uses, resistance. Antimicrobials. Antivirals. Antifungals. Antineoplastic agents for chemiotherapy and novel drugs for target therapy.
Cardiovascular drugs: Anti-hypertensive, Antianginal, Antiarrhythmic treatments. beta blockers and other medications for congestive heart
failure.
Drugs for the treatment of dyslipidemia.
Drugs affectin the emostatic system: anticoagulants and antiplatelet agents. Fibrinolytics. The hematopoietic system drugs.
Kidney drugs. Diuretics and antidiuretics.
Drugs of the respiratory system. Antiasmatic and Antitussive treatments.
Gastrointestinal system drugs. Anti-ulcer and gastroprotective drugs.
Drugs of intestinal motility: prokinetic and antispastic medicaments.
Emetics, antiemetics. Laxatives.
Treatment of the inflammation: Anti-inflammatory drugs (NSAIDs and steroid). Drugs for chronic inflammations (ulcerative colitis, Crohn' disease, rheumatoid artritis).
Autacoids: Histamine and antihistamines. Serotonin and serotonin antagonists.
Endocrine pharmacology. Insulin and oral hypoglycemic. Glucocorticoids and mineralcorticoids. Estrogen and progestinic. Thyroid medications.
Hypothalamic and pituitary hormones.
Drugs for benign prostatic hypertrophy.
Drugs for erectile dysfunction.
Prescription of drugs.

Bibliography

Rang, Dale et al., Pharmacology - Elsevier;
Katzung: Pharmacology (last ed.);
Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)

Teaching methods

The course will be held through lectures. In case the COVID-related
emergence continues, frontal lessons will proceed remotely through the
Teams platform (for instructions, see http://selma.unipr.it). Lessons will
be carried out with the aid of iconographic material collected in
Programma esteso Farmacologia del sistema autonomo e somatico: trasmissione colinergica
e adrenergica.
Farmaci colinergici: agonisti diretti e indiretti; antagonisti muscarinici.
Farmaci del sistema adrenergico: agonisti e antagonisti recettoriali
specifici. Stimolanti adrenergici centrali: cocaina, amfetamina,
metilfenidato.
Farmaci stimolanti e bloccanti gangliari: nicotina e ganglioplegici
Bloccanti neuromuscolari competitivi e depolarizzanti.
Farmaci del sistema nervoso centrale: anestetici generali e locali,
sedativo-ipnotici, Ansiolitici, antiepilettici, spasmolitici centrali. Farmaci
antiparkinson e delle malattie neurodegenerative. Antipsicotici e
Antidepressivi.
Analgesici oppioidi e non-oppioidi. Composti d'abuso.
Chemioterapici: Generalità, definizione, usi, meccanismi d'azione,
resistenza. Antimicrobici. Antivirali. Antimicotici. Antineoplastici.
Farmaci cardiovascolari: Anti-ipertensivi. Antianginosi. Antiaritmici.
Farmaci per l'insufficienza cardiaca congestizia. Farmaci per il
trattamento delle dislipidemie.
Farmaci della coagulazione: anticoagulanti e antiaggreganti. Farmaci
della fibrinolisi. Farmaci del sistema emopoietico.
Farmaci del rene. Diuretici e antidiuretici.
Farmaci del sistema respiratorio. Antiasmatici. Antitosse.
Farmaci del sistema gastroenterico. Farmaci antiulcera e gastroprotettori.
Farmaci della motilità intestinale: procinetici e antispastici. Emetici,
antiemetici. Lassativi.
Farmaci dell'infiammazione. Anti-infiammatori non steroidei (FANS). Antiinfiammatori
steroidei. Antigottosi.
Autacoidi: Istamina e anti-istaminici. Serotonina e antagonisti.
Farmacologia endocrina. Insulina e ipoglicemizzanti. Gluco- e mineralcorticoidi.
Estrogeni e progestinici. Farmaci della tiroide. Ormoni
ipotalamici e ipofisari. Farmaci per l'ipertrofia prostatica benigna. Farmaci
per le disfunzioni erettili.
La ricettazione.
Obiettivi per lo sviluppo sostenibile
Codice Descrizione
PowerPoint files that, at the end of the course, will be made available to
students on the Elly site at the course pages.

Assessment methods and criteria

Oral examen.
In case of the persistence of the health emergency, the exams will be
conducted remotely, as follows:
remote oral questions, through the Teams platform (guide
http://selma.unipr.it/).
Students with SLD / BSE must first contact Le Eli-che: support for
students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/leeli-
che-supporto-studenti-con-disabilita-dsa-bes)

Other information

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