cod. 21954

Academic year 2012/13
1° year of course - First semester
Academic discipline
Biochimica (BIO/10)
Scienze biomediche
Type of training activity
16 hours
of face-to-face activities
2 credits
hub: -
course unit
in - - -

Learning objectives

Knowledge of structure and function of nucleic acids, proteins, carbohydrates and lipids. Comprehension of the foundations of Metabolic Pathways.


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Course unit content

Organic chemistry, Structural and Metabolic Biochemistry

Full programme

A) Organic chemistry foundations.

Nucleotides and nucleic acids. Nucleotides chemistry and nucleic acids structures. Biological role of DNA, tRNAs, mRNA, and ribosomal RNA.

Aminoacids, peptides and proteins. Amino Acids classification; the peptide bond. The covalent structure of proteins: overview of protein structure. Protein folding and protein functions.

Hemoglobin: structure and function. Oxygen binding and transport at the molecular level. Factors affecting oxygen affinity.

How Enzymes Work. Classification of enzymes.

Lipids. Classification, structure and functions of fatty acids, triglycerides and cholesterol. Structural lipids in membranes.

Carbohydrates. Structure and classification of monosaccharides and disaccharides and polysaccharides.

Free Energy and spontaneous reactions. Thermodynamics of biological reactions, ATP as energy carrier.

Cellular metabolism. Oxidation and degradation reactions, biosynthetic reactions.

Mitochondrial reactions. Coenzymes and biological redox reactions. Electron-transfer reactions in mitochondria: components and functions. ATP synthesis. Regulation of Oxidative Phosphorylation.

Glycolysis, Gluconeogenesis, Glycogen metabolism, The Citric Acid Cycle.

Fatty acids and aminoacidic metabolism.

Hormonal regulation and integration of metabolism. Insulin and glucagon. Liver, muscle and brain metabolism.


Le basi della biochimica
di Champe Pamela C. - Harvey Richard - Ferrier Denise R.
Editore: Zanichelli

Teaching methods

Frontal lessons aided by presentations and animations files.

Assessment methods and criteria

Oral exam.

Other information

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