Learning objectives
The understanding of structure-dynamics-function relationships.
The understanding of the main metabolic pathways and regulation mechanisms
Prerequisites
Knowledge og general chemistry and organic chemistry
Course unit content
The logics of living organisms
Molecular and macromolecular components of cells
Bond and intra and intermolecular interactions
Protein structure, dynamics and function
Antibodies
Myoglobin and hemoglobin
Allostery and allosteric models
Enzymes,and coenzymes
Catalytic mechanism, inhibition and regulation
Lipids and biological membranes
Carbohydrates
Principles of metabolism and bioenergetics
Glycolysis, pentose phosphate pathway, gluconeogenesis, hormon regulation of glycogen formation and degradation.
Degradation and synthesis of fatty acids
Keton bodies
Synthesis and degradation of heme
Krebs Cycle
Oxidative phosphorylation, ATP synthesis
Synthesis and degradation of aminoacids, urea cylcle
Synthesis and degradation of purine and pyrimidinic bases
Bibliography
Cambell e Farrell BIOCHEMISTRY Devlin BIOCHEMISTRY,
Garrett and Grisham PRINCIPLES OF BIOCHEMISTRY
Mathews and van Holde BIOCHEMISTRY
Nelson and Cox PRINCIPLES OF BIOCHEMISTRY
Stryer BIOCHEMISTRY
Voet and Voet BIOCHEMISTRY