Learning objectives
The student should (1) know the most commonly prescribed laboratory analyses in clinical pathology, (2) understand their role in diagnostic procedures, follow up and therapy monitoring, (3) properly evaluate their cost/benefit ratio and (4) apply this information to relevant clinical examples.
Prerequisites
Mandatory propedeutic examinations are defined by the Course Council.
Relevant bases of Biochemistry, Physiology, Immunology and General Pathology should be adequately recalled.
Course unit content
The first lessons cover general topics regard to biological materials and
preparation of the patient.
The second part of the course covers the main laboratory tests, in relation
to the work activity.
The following issues will be addressed: - The laboratory in hematology. - Laboratory evaluation of hemostasis. - Systemic parameters of inflammation - Bases of immunopathology: Ipesrnsibility I type and Immunodeficiencies.
Full programme
A) Clinical pathology in hematology:
- Complete blood count (CBC)
- Anemia (sideropenic, of chronic disease, aplastic; sideroblastic, B12 and folate deficiency; hemolytic)
- Hemoglobinopathies
- Disorders of white blood cells
- Disorders of iron metabolism
- Lymphoproliferative and myeloproliferative disorders
B) The laboratory in hemostasis:
- Bleeding disorders: alterations of primary and secondary hemostasis
- Thromboembolic disease and thrombophilia
- DIC
- Monitoring of anticoagulant therapies
C) Inflammation and immunity:
- ESR and acuta phase proteins
- Complement, cytokines and chemokines
- Antibodies
- Cellular immunity
D) Bases of immunopathology:
- Autoimmune diseases
- Immunodeficiency
- IgE-mediated hypersensitivity
Bibliography
Antoniozzi, Gulletta (eds.) Medicina di laboratorio Logica & Patologia Clinica III ed., Piccin, Padova, 2019
M. Ciaccio, G. Lippi: Biochimica Clinica e Medicina di Laboratorio - EdiSes (ultima edizione)
The slides used during the lectures will be made available on the Elly Platform.
Teaching methods
The course will be conducted through interactive lectures in front of the students, with the aid of illustrative material that, at the end of the course, will be made available to students on Elly site at the pages of the course.
Lectures will be held on-site in compliance with safety standards, provided that further instructions are not implemented.
During the lessons we will discuss the issues related to laboratory tests and their interpretation topic will be exposed, encouraging students to ask questions on the basis of references that will be provided.
Assessment methods and criteria
Verification tests in progress will not be carried out. Final assessment will be carried out through oral examination, aiming to evaluate the communication and learning skills of the student, as well as his/her ability to judge the health status of the hypothetical patients.
When required, the exams will be conducted remotely through the Teams platform (guide http://selma.unipr.it/).
Students with SLD / BSE must first contact “Il centro accoglienza e inclusione” (https://www.cai.unipr.it/)).
Each student will be asked questions on topics listed in the extended program. The inability to answer a question (or at least ascertained inability to provide a correct definition of the pathological phenomenon subject of the application) will result in not passing the exam.
The student will be evaluated with votes ranging from 0 to 30, with 18 being the lowest vote to positively pass the exam. The final vote will be decided by mutual agreement among the teachers of the integrated course.
Other information
