Learning objectives
At the end of the course, the student should have acquired knowledge about the principles and applications of the Process Analytical Chemistry, which is exploited in industry.
In particular, the student should:
- be able to differentiate the approach of chemical process analysis from that of "classical" laboratory analysis
- demonstrate to know and be able to describe the main techniques and strategies used to control an industrial process, thus ensuring the quality of the final product and / or optimize the performance
- to be able to explain how analytical process chemistry fits into a multidisciplinary approach, which also involves the use of chemiometric techniques for data analysis and predictive statistical model building
- be able to connect each other the different topics addressed during the course and to connect them with the basic and related disciplines, as well as to discuss concepts critically and to consult relevant scientific literature.
Prerequisites
For the course, it will be fundamental the knowledge of instrumental analytical chemistry and chemometrics.
Course unit content
- Aims of process analytical chemistry and its applications in industrial processes. Role of analytical chemistry in the chemical / pharmaceutical industry
- Process analytical chemistry as part of the quality control and quality assurance system
- Instrumental techniques on which process analyzers are based (eg spectroscopy, chromatography, sensors, mass spectrometry) and their interfacing to chemical processes
- Main chemometric techniques applied to process analytical chemistry
- Examples from current literature and discussion of scientific articles
Full programme
- Aims of process analytical chemistry and its applications in industrial processes. Role of analytical chemistry in the chemical / pharmaceutical industry
- Process analytical chemistry as part of the quality control and quality assurance system
- Instrumental techniques on which process analyzers are based (eg spectroscopy, chromatography, sensors, mass spectrometry) and their interfacing to chemical processes
- Main chemometric techniques applied to process analytical chemistry
- Examples from current literature and discussion of scientific articles
Bibliography
“Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries”, Edited by Katherine A. Bakeev, 2nd Edition, 2010.
“Process Analytical Chemistry. Control, Optimization, Quality, Economy”, by Karl Heinz Koch, Springer Ed., 1999.
Scientific articles and other material necessary for the preparation of the exam or useful for any further supplementary study are uploaded to the Elly platform, or expressly indicated in slides available on Elly.
Teaching methods
The teaching activities will involve frontal lessons supported by concrete examples and study of significant cases, concerning the application of the analytical process chemistry, taken from the most recent scientific literature.
The slides used as lesson support will be available for download on the Elly platform, where are regularly uploaded.
Slides are an integral part of the didactic material. It is important to remind that non-attending students have to check the available teaching material and the directions provided by the teacher through the Elly platform.
Assessment methods and criteria
The assessment of the student learning is carried out through a final oral examination, the vote of which is immediately communicated at the end of the exam. The student must demonstrate the understanding of the fundamental concepts of each topic, he/she have to be able to discusses in a critical and applicative point of view the issues dealt with and to possess a proper mastery of the scientific language.
Other information
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