Learning objectives
The student is asked to understand and learn the content of the course. Attendance to lessons, which is mandatory, will allow the student to acquire skills appropriate to describe, communicate effectively, use independence of judgment and comment the mechanisms of metabolic energy production, energetic and structural homeostasis of living cells; structure and function of eukaryotic genes, replication of DNA, gene expression, DNA repair; the main metabolic pathways and their regulation; structure and functions of hormones, endocrine regulation of the metabolism; metabolic and biochemical correlations between organs and tissues under normal and pathological conditions; the molecular basis of human diseases; research approaches to molecular medicine and translational research.
Prerequisites
To be eligible for Human Biochemistry exam, at the end of the second year of the course, students must have passed the following examinations:
1) Chimica e Propedeutica Biochimica
2) Istologia
3) Biochimica e Biologia Molecolare
Course unit content
The course will address the complexity of human metabolism and its regulation, laying the fundamentals for understanding of diseases, diagnosis, treatment at the molecular level, also illustrating the most advanced aspects of translational research.
Bioenergetics and biological oxidation. Glycolysis and the metabolic fate of pyruvate. Glycogen metabolism. Gluconeogenesis. Control of glycemia. Pentose Phosphate pathway. Citric Acid cycle and its amphibolic role. Electron transport and oxidative phosphorylation. Amino acid metabolism. Metabolism of fatty acids and lipids. Ketogenesis. Cholesterol metabolism. Transport of lipids and lipoproteins. Metabolic fate of ammonia. Urea Cycle. Synthesis of uric acid. Synthesis and catabolism of heme. Bile pigments. Biosynthesis of amino acids. Biosynthesis of Purines, Pyrimidines and nucleotides. Biochemistry of the endocrine system. Structural and functional classification of hormones. Hormones: signal transduction pathways. Role of hormones in metabolism. Molecular approaches to major human diseases, molecular and translational medicine.
Full programme
Bioenergetics and biological oxidation. Glycolysis and the metabolic fate of pyruvate. Glycogen metabolism. Gluconeogenesis. Control of glycemia. Pentose Phosphate pathway. Citric Acid cycle and its amphibolic role. Electron transport and oxidative phosphorylation. Amino acid metabolism. Metabolism of fatty acids and lipids. Ketogenesis. Cholesterol metabolism. Transport of lipids and lipoproteins. Metabolic fate of ammonia. Urea Cycle. Synthesis of uric acid. Bile pigments. Biosynthesis of amino acids. Biosynthesis of Purines, Pyrimidines and nucleotides. Biochemistry of the endocrine system. Structural and functional classification of hormones. Hormones: signal transduction pathways. Role of hormones in metabolism. Molecular approaches to major human diseases, molecular and
Bibliography
Nelson DL, Cox MM: I principi di Biochimica di Lehninger, Zanichelli, Bologna.
Lewin, Krebs, Goldstein, Kilpatrick: Il gene. Zanichelli, Bologna.
Amaldi, Benedetti, Pesole, Plevani: Biologia Molecolare. Casa Editrice Ambrosiana, Milano.
Lieberman, Marks: Biochimica Medica, un approccio clinico. Casa Editrice Ambrosiana, Milano.
Baynes JW, Dominiczak MH: Biochimica per le discipline biomediche, Elsevier Mosby, Philadelphia.
Caldarera CM: Biochimica Sistematica Umana, CLUEB, Bologna.
Devlin TM: Biochimica con aspetti clinici. Wiley-Liss, New York.
Garrett RH, Grisham CM: Biochimica. Piccin, Padova.
Mathews CK, van Holde KE, Ahern KG: Biochimica, Casa Editrice Ambrosiana, Milano.
Murray RK, Granner DK, Mayes PA, Rodwell VW; Harper Biochimica, McGraw-Hill Libri Italia srl, Milano.
Siliprandi, Tettamanti: Biochimica Medica, Piccin. Padova.
Voet D, Voet JG: Biochimica John Wiley & Sons, USA.
Teaching methods
The course will be held with oral lectures and seminars to deep single issues, and will make use of multimedia systems. During the lessons, students will have the opportunity to discuss the key aspects of the course. Teachers will be available throughout the duration of the course to answer questions and support students during their training with individual meetings by appointment.
Assessment methods and criteria
The final examination, at the end of the second year of the course, includes an oral examination on the main topics of program. Please refer to the detailed program below.
Other information
Support activities
The teaching material has been moved to the E-Learning University web site -> lea.unipr.it, which is accessible by clicking on the “Go” button at the bottom of Moodle. Availability and updates of teaching materials are subject to approval by the competent authorities of the University.
Access to the restricted section of the course by individual student is through username and password. The student will book the exam list following login. Exams lists are accessible and scheduled annually.
2030 agenda goals for sustainable development
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