Learning objectives
Be able to describe and discuss the characteristics, structure function and the mechanism of action of vitamins. Know and apply the knowledge about the biochemical mechanisms of blood coagulation. Know and apply the knowledge about the biochemical mechanisms of maintenance of calcium homeostasis.
Prerequisites
To be eligible to take the examination of Biochemistry and Systematic Human Dynamics at the end of the second year of the course, students must have passed the examinations:
1) Introductory Biochemistry and Chemistry
2) Histology
Course unit content
Structure functions and mechanism of action of vitamins. Biochemical mechanisms of blood coagulation. Biochemical mechanisms of calcium homeostasis.
Full programme
Vitamins: nutritional aspects, structure, mechanism of action. Vitamin A and the mechanism light perception. Coordinated actions of vitamin D and parathyroid hormone in the regulation of serum calcium. Vitamin K: role in the maturation of clotting factors. Blood coagulation: molecular events of the intrinsic, extrinsic and common pathway. Mechanisms of clot dissolution.
Bibliography
Nelson DL, Cox MM: I principi di Biochimica di Lehninger, Zanichelli, Bologna.
Lewin, Krebs, Goldstein, Kilpatrick: Il gene. Zanichelli, Bologna.
Amaldi, Benedetti, Pesole, Plevani: Biologia Molecolare. Casa Editrice Ambrosiana, Milano.
Lieberman, Marks: Biochimica Medica, un approccio clinico. Casa Editrice Ambrosiana, Milano.
Baynes JW, Dominiczak MH: Biochimica per le discipline biomediche, Elsevier Mosby, Philadelphia.
Caldarera CM: Biochimica Sistematica Umana, CLUEB, Bologna.
Devlin TM: Biochimica con aspetti clinici. Wiley-Liss, New York.
Garrett RH, Grisham CM: Biochimica. Piccin, Padova.
Mathews CK, van Holde KE, Ahern KG: Biochimica, Casa Editrice Ambrosiana, Milano.
Murray RK, Granner DK, Mayes PA, Rodwell VW; Harper Biochimica, McGraw-Hill Libri Italia srl, Milano.
Siliprandi, Tettamanti: Biochimica Medica, Piccin. Padova.
Voet D, Voet JG: Biochimica John Wiley & Sons, USA.
