Learning objectives
The course is divided into theoretical lectures and practical exercises and
has been designed to provide students with knowledge on the most
useful analysis methods for separation, identification and purity control of
substances of pharmaceutical interest.
Prerequisites
Students should have passed the Organic Chemistry examination to
attend the Drug Analysis II laboratory.
Course unit content
Safety rules and elements of first aid in the chemical-pharmaceutical
laboratory.
Explanation and use of the Official Italian Pharmacopoeia and of the
European Pharmacopoeia.
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Drug isolation and purification techniques: extraction using solvents,
crystallisation, distillation, sublimation, chromatographic methods.
Measurement of physical constants: boiling point, fusion point, specific
rotatory power.
Chromatographic techniques applied to drug recognition.
Spectrophotometric methods for drug identification.
Identification of organic substances:
preliminary tests: organoleptic examination, behaviour during
combustion, solubility, qualitative elementary analysis;
recognition assays of the main functional groups and preparation of
crystalline derivatives (amines, carbonyl compounds, carboxylic acids,
alcohols, phenols, nitro compounds, carbohydrates, amino acids).
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Recognition assays of organometallic and inorganic substances of
pharmaceutical interest.
Recognition of organic, organometallic and inorganic substances included
in the Official Pharmacopoeia: identification reactions and purity control.
Limit assays.
Full programme
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Bibliography
• A. Carta, M.G. Mamolo, F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa, EdiSES - V.Cavrini, V. Andrisano, Analisi farmaceutica, Società Editrice Esculapio • F.Savelli, O.Bruno, Analisi Chimico Farmaceutica, Edizioni Piccin • Farmacopea Ufficiale della Repubblica Italiana, Ultima Edizione • Farmacopea Europea, Ultima Edizione
Teaching methods
The courses is divided into theoretical lectures and practical activities.
Assessment methods and criteria
The examination consists of a practical test (recognition of two
substances included in the Official Pharmacopoeia), a written test
and an oral test covering all the topics of the course syllabus.
Other information
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