Learning objectives
The course is structured with theoretical lectures and practical exercises. It aims to provide the student with knowledge of chemical analysis useful in recognizing and evaluating the purity of compounds of pharmaceutical interest.
Prerequisites
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Course unit content
Basic information on safety in the laboratory. • Guide to the use of the Italian Official Pharmacopoeia and European Pharmacopoeia. • Systematic analysis of inorganic, organometallic and organic drugs. • Preliminary tests: organoleptic, ignition. Solubility, dissolution process, types of solvents, the structure-solubility relationship• Determination of chemical and physical properties: melting point, boiling point. • Methods of separation and purification: crystallization, sublimation, distillation, extraction. • Organic Elemental analysis. Assays for the main functional groups and the preparation of crystalline derivatives (amines, carbonyl compounds, carboxylic acids, alcohols, phenols, nitro compounds, carbohydrates, amino acids). • Chromatographic techniques applied to the identification of drugs. • spectrophotometric methods for the identification of drugs. • Identification of drugs registered in the Official Pharmacopoeia: reactions of identification and control of purity.
Full programme
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Bibliography
A. Carta, M.G. Mamolo, F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa, EdiSES - V.Cavrini, V. Andrisano, Analisi farmaceutica, Società Editrice Esculapio • F.Savelli, O.Bruno, Analisi Chimico Farmaceutica, Edizioni Piccin • Farmacopea Ufficiale della Repubblica Italiana, Ultima Edizione • Farmacopea Europea, Ultima Edizione
Teaching methods
Theoretical lectures and laboratory practice
Assessment methods and criteria
Practice laboratory test and written exam
Other information
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