Learning objectives
To bring mechanisms and nature of toxic effects of drugs and xenobiotics to student's knowledge.
Prerequisites
Pharmacology examination
Course unit content
General part
First principles of toxicity
Mechanisms and tests of toxicity
ADME of toxic substance
Metabolism of xenobiotics
Cancerogenesis, teratogenesis and mutagenesis
Special part
Experimental toxicology and evaluation of toxicological risks
Idiosincrasic and allergic reactions.
Interactions between xenobiotics
Metals, Solvents, Pesticides, IPA, PCOD, PCB
Enviromental toxicoogy
Alimentary toxicology
Occupational toxicology
Toxicology of biotecnological products
Toxicology of herbal products
Poisons and antidotes
Toxicology of:
Lung
Kidney
Liver
Cardiovascular Sistem
Central Nervous Sistem (CNS)
Full programme
- - -
Bibliography
Recommended readings:
CASARETT & DOULL’S: "Tossicologia: I fondamenti dell’azione delle sostanze tossiche", 6° Edizione. Ed. EMSI, Roma.
Piera Ghi: “Tossicologia: principi e applicazioni all’uso dei farmaci e dei prodotti della salute”. Edizione Minerva Medica
C.L. GALLI, E. CORSINI, M. MARINOVICH “Tossicologia”. Edizione Piccin
W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.
GOODMAN & GILMAN’S: "The pharmacological basis of therapeutics"
ERNEST HODGSON: “Tossicologia Moderna”, EdiSES
Teaching methods
Oral lesson
Assessment methods and criteria
Oral examination
Other information
The oral examination will be about the entire program. Students have to show to have a good comprension of principal parts of each topic.