Biotechnology | University of Parma

SYSTEM BIOLOGY
cod. 1004399

Professor

Academic discipline

Biologia applicata (BIO/13)

Field

A scelta dello studente

Type of training activity

Student's choice

42 hours
of face-to-face activities

6 credits

hub: PARMA

course unit
in - - -

Learning objectives

To provide the knowledge necessary to understand the relevance of System biology in the modern biotechnologies

Prerequisites

- - -

Course unit content

Introduction on System Biology in the context of modern biotechnology

Pathways, networks and systems in biology

Contribution of genomics to system biology

Properties of networks, general definitions

Physical networks and logical networks

Networks as graphs

Dynamics, stability, robustness - redundancy in networks

Interactions in networks and in biological functions: pathways, nodes

Distribution of grades in networks

The concept of “hub”

Random networks and biological networks

Metabolic networks

Ezamples of networks with transcription factors and DNA sequence: experimental approaches to study these networks

Examples of networks in yeast: experimental and computational approaches

Examples of networks with interactions among proteins: interactomes

Methods to identify protein-protein and protein-DNA interactions

Biological properties of hubs: conservation, robustness, duplications

Limitations in interactomes

Networks for gene regulation, protein-DNA interactions

Lactose operon in Escherichia coli

Examples in Caenorhabditis elegans, Saccharomyces cerevisiae and other organisms

Full programme

- - -

Bibliography

Material provided by the lecturer

Teaching methods

frontal lectures and seminars

Assessment methods and criteria

oral examination

SYSTEM BIOLOGY cod. 1004399