Learning objectives
Introduction of the student to the basic conceps of human genetics , from quantitative and population genetics to the molecular basis of heredity following the genetic information flow from DNA to gene expression
Analysys of the mechanisms of genetic diversity generation and conservation.
Analysys of the coordinate expression in space and in time of genes during development.
Analysis of the role of mutational mechanisms in genetic disease onset.
Prerequisites
- - -
Course unit content
Quantitative genetics and population genetics.
Nucleic acids chemistry.
DNA replication. DNA in eukariotic chromosomes
Transcription, translation and regulatin of gene expression in prokaryotes and eukaryotes.
RNA interference.
The genetic code.
Generation and conservation of genetic diversity: general homologous recombination, site specific recombination, mobile genetic elements.
Chromosomal mutations, gene mutation and their mechanisms.DNA repair.
Gennes and development.
Full programme
- - -
Bibliography
Thompson & Thompson Genetics in Medicine Nussbaum RL McInnes RR Willard HF eds, Saudrs Elsevier pub., Philadelphia 2007
Teaching methods
Oral lectures, laboratory practice with test
Assessment methods and criteria
Written examination
Other information
- - -
