Learning objectives
The aim of the course is to give basic knowledge for the comprehension of causes and mechanisms of diseases at cellular and organ level. The correlation between tissue alterations (and/or control mechanisms) and organ functions will allow to face more complex pathologic processes.
Prerequisites
The comprehension of the matter requires a good knowledge of histology, anatomy, biochemistry and physiology.
Course unit content
CELL INJURY, ADAPTATIONS, AGING AND DEATH
Causes and mechanisms of cell injury; Intracellular and extracellular accumulations;
Adaptations: atrophy – hypertrophy – hyperplasia – metaplasia – dysplasia;
Cellular aging; Cell death
TISSUE RESPONSES TO INJURY
Acute and chronic inflammation; Tissue repair – regeneration, healing, fibrosis
DISORDERS OF THE IMMUNE SYSTEM
Hypersensitivity; Autoimmune diseases; Immunodeficiences; Amiloidosis
NEOPLASIA
Classification, nomenclature and epidemiology; Morphological features of tumor cells; Benign and malignant neoplasms; Carcinogenesis; Malignant transformation;
Tumor markers and prognosis
PATHOPHYSIOLOGY OF THE BLOOD VESSELS AND THE HEART
Electrocardiography and ecocardiography; Arrhythmogenesis; Hypertension; Cardiac failure; Arteriosclerosis and atherosclerosis; Aneurysms; Thrombosis; Myocardial infarction
PATHOPHYSIOLOGY OF THE CARBOHYDRATE METABOLISM
Diabetes mellitus
PATHOPHYSIOLOGY OF BLOOD CELLS
Hematopoiesis; Evaluation of hematopoietic function; Myeloid and lymphoid neoplasms; Anemias: classification, examples and laboratory diagnosis
PATHOPHYSIOLOGY OF THE COAGULATION
Bleeding disorders; CID
PATHOPHYSIOLOGY OF THE LIVER
Jaundice; Hepatitis; Cirrhosis
Full programme
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Bibliography
Robbins – Pathologic Basis of Disease, Elsevier Saunders.
Rubin – Patology, ed. Lippincott Williams& Wilkins
Teaching methods
Frontal lessons and electronic material
Assessment methods and criteria
Oral exam
Other information
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