Learning objectives
The objectives of the course are to enable the acquisition of knowledge and understanding about etio-pathogenetic mechanisms of tumor origins and progression.
Great emphasis will be given to molecular oncology in order to allow the student to apply the knowledge gained to the understanding of the mechanisms of drug action and to acquire useful skills for future employment.To know how to communicate learned information and knowledge to experts and not experts.
Prerequisites
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Course unit content
Molecular and cellular oncology
Full programme
Neoplasia. Definitions and nomenclature. Benign and malignant neoplasms. Grading and staging of tumors. Molecular basis of cancer. Oncogenic DNA and RNA virus. Protooncogenes, oncogenes, and oncoproteins. Tumor suppressor genes. Survival and pro-apoptotic genes. DNA repair genes. Molecular basis of multistep carcinogenesis. Angiogenesis. Tumor progression. Invasion and metastasis. Chemical carcinogenesis: initiation and promotion. Carcinogenic chemicals. Radiation carcinogenesis. Microbial carcinogenesis. Genetic predisposition to cancer. Effects of tumours on the host. Nutritional and hormonal effects. Biological basis of anti-neoplastic therapies. Study of biology, classification, and therapy of breast, lung, gastric, colon cancer, and melanoma.
Bibliography
Robbins e Cotran: Le Basi Patologiche delle Malattie. Edra IX edizione.
Pontieri-Russo-Frati: Patologia Generale.Piccin IV edizione
Teaching methods
Lectures will be held on-site. Supporting material will be available on the specific,
student-reserved platform (Elly).
The topics in the program will be presented and discussed through
lectures trying to involve the student so that it can be an active part of
the lesson.
The teacher is available for further explanations in office or by distance
via Teams after e-mail appointment, or via chat on Elly platform.
Assessment methods and criteria
The assessment of the achievement of the objectives of the course provides a multiple-choice test. Through questions regarding the course content, it will be determined whether the student has achieved the goal of knowledge and understanding of the content and if he has reached the goal of applying the acquired knowledge.
Students with Specific Learning Disorders must contact the University Reception and Inclusion Centre in advance (cai@unipr.it).
Other information
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