MEDICAL PHARMACOLOGY
cod. 1010297

Learning objectives

Knowledge and understanding of pharmacokinetics and pharmacodynamics fundamentals

Prerequisites

Knowledge of basic disciplines (anatomy, physiology, istologybichemistry, general pathology).

Course unit content

General Pharmacology

Full programme

General pharmacology, cellular and molecular. pharmacology. Branches of pharmacology. Concept of drug,
Drug development: preclinical phase with toxicological tests, clinical Phases, pharmacovigilance.
Pharmacokinetics: absorption, distribution, biotransformation and elimination of drugs; clearance; half-life; bioavailability; pharamceutical forms and routes of drug administration.
Pharmacodynamics: mechanisms of action of drugs; Drug-receptor interaction; affinity, potency, efficiency; Drugs acting as agonists and/or antagonists; dose-response curve. Drugs acting at ion channels, carriers, DNA. Enzyme inhibitors.
Principles of interaction between drugs.
Modification of the response to drugs: tachyphylaxis, tolerance, drug resistance. Pharmacogenetics and idiosyncratic responses.
Drug toxicity.

Bibliography

Rang, Dale et al., Pharmacology - Elsevier;
Katzung: Pharmacology (last ed.);
Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)

Teaching methods

The course will be held through lectures. In case the COVID-related emergence continues, frontal lessons will proceed remotely through the Teams platform (for instructions, see http://selma.unipr.it). Lessons will be carried out with the aid of iconographic material collected in PowerPoint files that, at the end of the course, will be made available to students on the Elly site at the course pages.

Assessment methods and criteria

Oral exam (together with Special Pharmacology).
In case of the persistence of the health emergency, the exams will be conducted remotely, as follows:
remote oral questions, through the Teams platform (guide http://selma.unipr.it/).
Students with SLD / BSE must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/le-eli-che-supporto-studenti-con-disabilita-dsa-bes)
Oral exam (after the second part of the course).

Other information

2030 agenda goals for sustainable development