Learning objectives
The course, composed by theoretical lessons and individual practice
training, is aimed at providing the basic notions for the qualitative and
quantitative determination of substances of pharmaceutical interest. In
particular, during the practical training attention will be focused on the
qualitative analysis and quantitative determination of inorganic
compounds of pharmaceutical interest.
Prerequisites
It is necessary to have passed the exam of general and inorganic
chemistry to be able to attend the course.
Course unit content
Ist MODULE
1. Introduction to qualitative analysis. Organoleptic analysis. Solvent-free
analysis: combustion and flame test.
2. Safety and first aid procedures in the laboratory. Symbols, risk and
safety phrases. Hazard chemicals handling procedures. Lab notebook.
3. Basic laboratory techniques and operations: solubilisation, dilution,
concentration, precipitation, filtration, centrifugation, solubility.
4. Stoichiometry, redox reactions, equilibrium in solution, acids and
bases, solubility product, coordination compounds.
5. Qualitative analysis in aqueous solution: identification of cations
belonging to groups I-VI, analysis of anions, analysis of acid insoluble
residue..
6. Application of solvent-free assays and analysis in aqueous solution to
the identification of unknown inorganic samples.
IInd MODULE
1. Introduction to quantitative analysis. Sampling. Experimental error:
error types, precision and accuracy, standard deviation. Significant digits.
2. Primary standards and titration. Gravimetric and volumetric analysis.
3. Lab equipment and instrumentation: the analytical balance, burettes,
pipettes, volumetric flasks.
4. Acid-base titration. Analysis of the titration curve: indicator choice,
potenziometric determination of the final point. Non-acqueous titration.
5. Complexometric and redox titrations.
Full programme
Ist MODULE
1. Introduction to qualitative analysis. Organoleptic analysis. Solvent-free
analysis: combustion and flame test.
2. Safety and first aid procedures in the laboratory. Symbols, risk and
safety phrases. Hazard chemicals handling procedures. Lab notebook.
3. Basic laboratory techniques and operations: solubilisation, dilution,
concentration, precipitation, filtration, centrifugation, solubility.
4. Stoichiometry, redox reactions, equilibrium in solution, acids and
bases, solubility product, coordination compounds.
5. Qualitative analysis in aqueous solution: identification of cations
belonging to groups I-VI, analysis of anions, analysis of acid insoluble
residue..
6. Application of solvent-free assays and analysis in aqueous solution to
the identification of unknown inorganic samples.
IInd MODULE
1. Introduction to quantitative analysis. Sampling. Experimental error:
error types, precision and accuracy, standard deviation. Significant digits.
2. Primary standards and titration. Gravimetric and volumetric analysis.
3. Lab equipment and instrumentation: the analytical balance, burettes,
pipettes, volumetric flasks.
4. Acid-base titration. Analysis of the titration curve: indicator choice,
potenziometric determination of the final point. Non-acqueous titration.
5. Complexometric and redox titrations.
Bibliography
ARANEO: “Chimica analitica qualitativa. Nuovo metodo periodale”,
Ambrosiana Ed. BARBETTIHOGNESS, JOHNSON, ARMSTRONG “Analisi
qualitativa ed equilibrio chimico”, Piccin Ed.HARRIS D.C., “Chimica
Analitica Quantitativa”, Zanichelli Ed
Teaching methods
Theory classes and practical sessions in the laboratory
Assessment methods and criteria
Practical in itinere evaluations and written exam.
Other information
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