Learning objectives
Knowledge and understanding of pharmacokinetics and pharmacodynamics fundamentals
Prerequisites
Knowledge of basic disciplines (anatomy, physiology, istologybichemistry, general pathology).
Course unit content
General Pharmacology
Full programme
General pharmacology, cellular and molecular. pharmacology. Branches of pharmacology. Concept of drug,
Drug development: preclinical phase with toxicological tests, clinical Phases, pharmacovigilance.
Pharmacokinetics: absorption, distribution, biotransformation and elimination of drugs; clearance; half-life; bioavailability; pharamceutical forms and routes of drug administration.
Pharmacodynamics: mechanisms of action of drugs; Drug-receptor interaction; affinity, potency, efficiency; Drugs acting as agonists and/or antagonists; dose-response curve. Drugs acting at ion channels, carriers, DNA. Enzyme inhibitors.
Principles of interaction between drugs.
Modification of the response to drugs: tachyphylaxis, tolerance, drug resistance. Pharmacogenetics and idiosyncratic responses.
Drug toxicity. Prescription. Elements of phytotherapy.
Bibliography
Rang, Dale et al., Pharmacology - Elsevier;
Katzung: Pharmacology (last ed.);
Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)
Rossi et al., Farmacologia (IV ed., 2020), Edizioni Minerva Medica.
Teaching methods
The course will be held through lectures. In case the COVID-related emergence continues, frontal lessons will proceed remotely through the Teams platform (for instructions, see http://selma.unipr.it). The lessons will take place with the aid of iconographic material collected in presentations, which however I will not make available to students on the Elly platform, limited to the program of my competence. This is in order to encourage students to attend class.
Assessment methods and criteria
Oral exam (together with Special Pharmacology, at the fourth year).
In case of the persistence of the health emergency, the exams will be conducted remotely, as follows:
remote oral questions, through the Teams platform (guide http://selma.unipr.it/).
Students with SLD / BSE must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/le-eli-che-supporto-studenti-con-disabilita-dsa-bes)
Oral exam (after the second part of the course).
Other information
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