Learning objectives
The course is divided into theoretical lectures (in classroom, live in streaming and it will be possible to find the lessons on Elly) and practical experiences in lab, always face-to-face. The first part of the program involves the study of the safety rules fundamental for work in a medicinal-chemistry laboratory. Moreover, laboratory equipment and basic laboratory techniques and operations (solubilisation, dilution, precipitation, centrifugation, filtration) will be explained.
The second part of the course concerns the Qualitative Analysis: identification of anions and cations.
The second part of the course concerns the Quantitative Analysis: experimental error (types of errors, precision and accuracy), volumetric analysis, sampling, standard and normal solutions, choise of indicator, titrations (alkalimetry and acidimetry, redox, complexometric, potentiometric), quantitative analysis of active pharmaceutical ingredients by UV-VIS spectroscopy.and practical exercises and has been designed to provide students with knowledge of qualitative and quantitative analysis. In particular, during the practical training, attention will be focused on the acquisition of the basic laboratory techniques and on the safety procedures in lab.
Prerequisites
Students must have passed the General and Inorganic Chemistry examination to attend the Drug Analysis I laboratory.
Course unit content
The first part of the program involves the study of the safety rules fundamental for work in a medicinal-chemistry laboratory. Moreover, laboratory equipment and basic laboratory techniques and operations (solubilisation, dilution, precipitation, centrifugation, filtration) will be explained.
The second part of the course concerns the Qualitative Analysis: identification of anions and cations.
The second part of the course concerns the Quantitative Analysis: experimental error (types of errors, precision and accuracy), volumetric analysis, sampling, standard and normal solutions, choise of indicator, titrations (alkalimetry and acidimetry, redox, complexometric, potentiometric), quantitative analysis of active pharmaceutical ingredients by UV-VIS spectroscopy.
Full programme
- - -
Bibliography
¥ Hage, D.S.; Carr, J.D. Chimica Analitica e Analisi Quantitativa, PICCIN;
¥ Savelli, F.; Bruno, O. Analisi Chimico Farmaceutica, PICCIN.
¥ Cavrini V.; Andrisano V. Principi di Analisi Farmaceutica, ESCULAPIO
Teaching methods
The course is divided into theoretical lectures (in classroom, live in streaming and it will be possible to find the lesson on Elly) and practical activities in lab, always face-to-face. Moreover, many videos of the practical experiences will be published on Elly. It will be possible to find all the slide shown during the lessons on Elly.
Assessment methods and criteria
The examination consists of practical tests and of an oral test covering all the topics of the course.
If the health emergency persists, it will be necessary to replace the written test with an oral exam using Teams.
Other information
To achieve the objectives of the course, students will attend laboratories equipped with the instrumentation useful for the qualitative and quantitative analysis of compounds of pharmaceutical interest.
