Learning objectives
The objective of module 1 is the acquisition of the basic knowledge relative to functional cosmetics and cosmetic technology, both traditional and more innovative. The module gives the basic notions on the main raw products of cosmetic interest, on their functions, on the formulative techniques of the most relevant categories of cosmetics, as well as on the stability controls on finished products. The course covers also the European Regulatory Guidelines for Cosmetics, with particular regards to labeling and safety. The purpose of module 2 is to acquire a deep-rooted knowledge of the fundamental principles of the controlled drug delivery and innovative formulations (both marketed and in-development) and to develop the ability to apply these principles to different kind of formulations and administration route. A further aim of the course is to provide the students the tools for the elaboration of the information given so as to integrate them into their knowledge. The expected learning outcomes are: 1. Knowledge and understanding: understanding of the functional mechanisms of the skin. Acquisition of the notions relative to functional cosmetics and to cosmetic technology. Ability to use the specific language and the correct terminology for cosmetic ingredients. have acquired specific knowledge on mechanisms, materials, processes and formulations. 2. Applying knowledge and understanding: capability to recognize the function of each excipient of a given cosmetic product and the possible interactions. Capability to formulate the main categories of cosmetic products (solutions, creams, lotions, detergents). Be able to compare the innovative formulations with the traditional ones. 3. Communication skills: ability to use the specific language for this specialistic discipline. Be able to present the characteristic of a cosmetic product also to a non-expert audience. Be able to present (orally or in writing) the topics studied in a clear way and using a correct technical language. 4. Making judgements: the capability to evaluate the quality of a cosmetic product as a function of its composition and its packaging. Be able to highlight, for every innovative formulation/administration route, potentialities, limits and impact on patient therapy. 5. Learning skills: capability to connect the different subjects studied among them and with the basic disciplines. Capability of continuous education, through the scientific publications in the field of cosmetology and pharmaceutical technology.
Prerequisites
Knowledge of pharmaceutical technology is required.
Course unit content
The contents of module 1 are:
Functions of cosmetic products: hygiene, eutrophy, aesthetic
Anatomy and physiology of the skin
Cosmetic raw materials: active moieties and excipients
Silicones for cosmetic use
Vehicles for cosmetic formulations: solutions, emulsions, suspensions
Innovative cosmetic formulations: liposomes, nanoparticles, multiple emulsions and microemulsions
Skin moisturizers
Skin care products
Skin Detergents
Cosmetic products for hair care
Skin aging
New active moieties: alfahydroxyacids
Vitamines in cosmetic
Effect of UV radiation on the skin: UV filters
Make-up products
Deodorants, Antiperspirants and Perfumes
Cosmetic for skin whitening
Stability of cosmetic formulations
European Regulatory Guidelines for Cosmetics
The contents of module 2 are:
The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following:
General topics
• INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE
• BIOAVAILABILITY – ABSORPTION
• POLYMERS FOR CONTROLLED DRUG DELIVERY
• DIFFUSIONE AND DISSOLUTION
Innovative formulations
• RESERVOIR
• MATRICES
• OSMOTIC SYSTEMS
• GASTRORETENTIVE SYSTEMS
• COLON DELIVERY
• MUCOADHESION
• MICROPARTICLES
• NANOPARTICLES
• LIPOSOMES
• HYDROGELS
Alternative administration routes
• TRANSDERMAL DRUG DELIVERY
• BUCCAL DRUG DELIVERY
• OCULAR DRUG DELIVERY
• ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS
Full programme
The contents of module 1 are: Functions of cosmetic products: hygiene, eutrophy, aesthetic Anatomy and physiology of the skin Cosmetic raw materials: active moieties and excipients Silicones for cosmetic use Vehicles for cosmetic formulations: solutions, emulsions, suspensions Innovative cosmetic formulations: liposomes, nanoparticles, multiple emulsions and microemulsions Skin moisturizers Skin care products Skin Detergents Cosmetic products for hair care Skin aging New active moieties: alfahydroxyacids Vitamines in cosmetic Effect of UV radiation on the skin: UV filters Make-up products Deodorants, Antiperspirants and Perfumes Cosmetic for skin whitening Stability of cosmetic formulations European Regulatory Guidelines for Cosmetics The contents of module 2 are: The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following: General topics • INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE • BIOAVAILABILITY – ABSORPTION • POLYMERS FOR CONTROLLED DRUG DELIVERY • DIFFUSIONE AND DISSOLUTION Innovative formulations • RESERVOIR • MATRICES • OSMOTIC SYSTEMS • GASTRORETENTIVE SYSTEMS • COLON DELIVERY • MUCOADHESION • MICROPARTICLES • NANOPARTICLES • LIPOSOMES • HYDROGELS Alternative administration routes • TRANSDERMAL DRUG DELIVERY • BUCCAL DRUG DELIVERY • OCULAR DRUG DELIVERY • ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS
Bibliography
A.V., Manuale del Cosmetologo, Ed. Tecniche Nuove (Milano) G.PROSERPIO, "Le basi della cosmetologia", Ed. SEPEM, Milano. BONADEO“ Prodotti Cosmetici, cosmetología e tecnología cosmetiche” Ed. Librería Cortina (Milano) Principi di tecnologie farmaceutiche, P. Colombo, P.L. Catellani, A. Gazzaniga, E. Menegatti, E. Vidale, Casa Editrice Ambrosiana Ed. 2004 Since some topics are not present in the book, specific texts (availabe at the library of the Department of Pharmacy) will be suggested.
Teaching methods
The course is organized with frontal lectures. The first lecture presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. Then, general topics such as bioavailability and bioequivalence, dissolution, diffusion, polymers, controlled release are presented. Finally, the different pharmaceutical formulations and alternative delivery routes are explained in detail.
Classes will be held in presence with the possibility of attending online (synchronous online classes).
Assessment methods and criteria
The summative evaluation of the knowledge acquired is made through a written exam, made of two partials relative to the two modules. The student should, then, after online enrollment:
a) pass a written exam during the official dates established by the Dipartimento di Scienze degli Alimenti e del Farmaco (Module of cosmetic products, weight 50% of the overall grade);
b) pass a written exam during the official dates established by the Dipartimento di Scienze degli Alimenti e del Farmaco (Module of innovative pharmaceutical formulations, weight 50% of the overall grade);
If the Covid-2 emergency continues, the students will be allowed to pass the exam online, always in written form.
Each written exam, duration 1 hour, consists of 6 open answer questions (score for each question varies from 0 to 3) and 12 multiple choice questions (score for each question varies from 0 to 1). Up to 2 points will be given for the communication skills of the student.
The student should demonstrate to have understood, and to be able to apply, the fundamental concepts of each subject studied. In particular, the evaluation of each module, expressed in thirtieths, will be made on the basis of the following criteria:
1. knowledge and comprehension (theoretical and practical) capability of the subjects studied;
2. Ability to make judgements and to connect the different subject studied among them;
3. communication skills and appropriate use of the technical language;
4. ability to learn and to elaborate the subjects studied.
The results of the exam are published on the portal ESSE3 (https://unipr.esse3.cineca.it/Home.do) within one week of the date of the exam. Students can see the exam, by appointment with the teacher.
A fac-simile of the examen is avaiable to the students on the Elly portal.
Other information
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