Learning objectives
AT the end of the course, the student should be able to:
Knowledge and understanding: To be acquainted with the chemical and the physico-chemical bases that regulate the operation of receptors; to understand the mechanisms through which small molecules activate or block nuclear or membrane receptors
Applying knowledge and understanding: The student must show to be able to synthesize their knowledge, their ability to analyze and understand the structure-activity relationships for classes of drugs through devising and sustaining critical arguments in the field of medicinal chemistry, proving to be able to have a professional approach to discipline
In addition, the teaching aims to achieve autonomy of judgment and Communicative Abilities.
Making judgments: Students will be able during the lessons, to interact with the themes suggested by the teacher and, even with the help of the recommended texts and teaching materials, be able to make independent judgments
Communication skills: The student must be able to clearly and critically present the results of their individual calculations, demonstrating knowledge of research topics carried out during the program
Learning skills: to be acquainted with a method of study and analysis that is tailored on the student and efficient, in order to extend the field of knowledge to different disciplines and in order to make his preparation suitable to higher-learning experiences.
Prerequisites
Organic Chemistry , Medicinal Chemistry , Biochemistry , Physiology , Pharmacology
Course unit content
1) Structure of receptors
- Binding receptor/molecule of interest
- inhibition of receptors
- In-depth analysis of peculiar classes of receptors
1) Nuclear receptors
- classification
- structure
- molecular basis
for transcriptional
- definition of a steroid hormone
- nomenclature and chemical structure of steroid hormones
- biosynthesis of steroid hormones
- mechanism of action of steroid hormones
2) Corticosteroids
3) Female sex hormones
4) Male sex hormones
5) Hyperlipoproteinemia and cardiovascular disease
- the cholesterol and other blood lipids
- cholesterol biosynthesis
- lipoproteins
- hyperlipoproteinemias
6) HMG - CoA reductase inhibitors ( statins )
7) Medicines to treat diabetes
- type 1 diabetes
- type 2 diabetes
8) Oral hypoglycemic
Full programme
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Bibliography
Gragam L. Patrick ,
Pharmaceutical Chemicals,
III edition Edises
Teaching methods
The course will be conducted through lectures . Each lesson is a teaching module unit , in which , for each topic , are given to the student the foundation for acquiring knowledge and understanding , and to apply the knowledge and understanding to the problem treated in the unit of learning module. Slides of the lesson can be retrieved on Elly provided the student is allowed to do so. Slides represent a complementary tools in the preparation of the student, who is recommended to use the book to fulfill his/her preparation.
Assessment methods and criteria
The final evaluation will be based on a oral exam.
The final exam will be made of questions to which the student must reply, also with the help of figures, designing structures of the molecules and reaction schemes. to each answer will be applied a score. The exam is passed when the final score is equal or more than 18/30, according to teacher judgement
Other information
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2030 agenda goals for sustainable development
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