DRUG ANALYSIS
Course unit partition: Cognomi A-Z

Academic year 2019/20
2° year of course - Second semester
Professor
- Marco RADI
Academic discipline
Chimica farmaceutica (CHIM/08)
Field
Ambito aggregato per crediti di sede
Type of training activity
Caratterizzante
99 hours
of face-to-face activities
8 credits
hub: PARMA
course unit
in ITALIAN

Course unit partition: DRUG ANALYSIS

Learning objectives

The course, composed by theoretical lessons and individual practice training, is aimed at providing the basic notions for the qualitative and quantitative determination of substances of pharmaceutical interest. In particular, during the practical training attention will be focused on the qualitative analysis and quantitative determination of inorganic compounds of pharmaceutical interest.

Prerequisites

Knowledge of general and inorganic chemistry

Course unit content

Ist MODULE
1. Introduction to qualitative analysis. Organoleptic analysis. Solvent-free analysis: combustion and flame test.
2. Safety and first aid procedures in the laboratory. Symbols, risk and safety phrases. Hazard chemicals handling procedures. Lab notebook.
3. Basic laboratory techniques and operations: solubilisation, dilution, concentration, precipitation, filtration, centrifugation, solubility.
4. Stoichiometry, redox reactions, equilibrium in solution, acids and bases, solubility product, coordination compounds.
5. Qualitative analysis in aqueous solution: identification of cations belonging to groups I-VI, analysis of anions, analysis of acid insoluble residue..
6. Application of solvent-free assays and analysis in aqueous solution to the identification of unknown inorganic samples.

IInd MODULE
1. Introduction to quantitative analysis. Sampling. Experimental error: error types, precision and accuracy, standard deviation. Significant digits.
2. Primary standards and titration. Gravimetric and volumetric analysis.
3. Lab equipment and instrumentation: the analytical balance, burettes, pipettes, volumetric flasks.
4. Acid-base titration. Analysis of the titration curve: indicator choice, potenziometric determination of the final point. Non-acqueous titration.
5. Complexometric and redox titrations.

Full programme

Ist MODULE
1. Introduction to qualitative analysis. Organoleptic analysis. Solvent-free analysis: combustion and flame test.
2. Safety and first aid procedures in the laboratory. Symbols, risk and safety phrases. Hazard chemicals handling procedures. Lab notebook.
3. Basic laboratory techniques and operations: solubilisation, dilution, concentration, precipitation, filtration, centrifugation, solubility.
4. Stoichiometry, redox reactions, equilibrium in solution, acids and bases, solubility product, coordination compounds.
5. Qualitative analysis in aqueous solution: identification of cations belonging to groups I-VI, analysis of anions, analysis of acid insoluble residue..
6. Application of solvent-free assays and analysis in aqueous solution to the identification of unknown inorganic samples.

IInd MODULE
1. Introduction to quantitative analysis. Sampling. Experimental error: error types, precision and accuracy, standard deviation. Significant digits.
2. Primary standards and titration. Gravimetric and volumetric analysis.
3. Lab equipment and instrumentation: the analytical balance, burettes, pipettes, volumetric flasks.
4. Acid-base titration. Analysis of the titration curve: indicator choice, potenziometric determination of the final point. Non-acqueous titration.
5. Complexometric and redox titrations.

Bibliography

ARANEO: “Chimica analitica qualitativa. Nuovo metodo periodale”, Ambrosiana Ed. BARBETTI
HOGNESS, JOHNSON, ARMSTRONG “Analisi qualitativa ed equilibrio chimico”, Piccin Ed.
HARRIS D.C., “Chimica Analitica Quantitativa”, Zanichelli Ed

Teaching methods

Theory classes and practical sessions in the laboratory

Assessment methods and criteria

Practical in itinere evaluations and written exam.

Other information

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