Learning objectives
The course is divided into theoretical lectures and practical exercises and has been designed to provide students with knowledge of qualitative and quantitative analysis. In particular, during the practical training, attention will be focused on the acquisition of the basic laboratory skills and on the safety procedures in lab.
Prerequisites
Students must have passed the General and Inorganic Chemistry examination to attend the Drug Analysis I laboratory.
Course unit content
The first part of the program involves the study of the safety rules fundamental to work in a medicinal-chemistry laboratory. Moreover, laboratory equipment and basic laboratory techniques and operations (solubilisation, dilution, precipitation, centrifugation, filtration) will be explained as well.
The second part of the course concerns the Qualitative Analysis: identification of anions and cations of pharmaceutical interest.
The third part of the course concerns the Quantitative Analysis: experimental error (types of errors, precision and accuracy), volumetric analysis, sampling, standard and normal solutions, choise of indicator, titrations (alkalimetry and acidimetry, redox, complexometric, potentiometric), quantitative analysis of active pharmaceutical ingredients by UV-VIS spectroscopy.
Full programme
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Bibliography
Hage, D.S.; Carr, J.D. Chimica Analitica e Analisi Quantitativa, PICCIN;
Savelli, F.; Bruno, O. Analisi Chimico Farmaceutica, PICCIN.
Cavrini, V.; Andrisano, V; Principi di Analisi Farmaceutica, Società Editrice Esculapio
Teaching methods
The course is divided into theoretical lectures and practical activities with individual positions
Assessment methods and criteria
The examination consists of practical tests and of a written test covering all the topics of the course.
Other information
To achieve the objectives of the course, students will attend laboratories equipped with the instrumentation useful for the qualitative and quantitative analysis of compounds of pharmaceutical interest.
2030 agenda goals for sustainable development
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