cod. 1005716

Academic year 2017/18
4° year of course - Second semester
Academic discipline
Patologia generale (MED/04)
A scelta dello studente
Type of training activity
Student's choice
32 hours
of face-to-face activities
4 credits
course unit

Learning objectives

The objectives of the course are to enable the acquisition of knowledge and understanding about etio-pathogenetic mechanisms of tumor origins and progression.
Great emphasis will be given to molecular oncology in order to allow the student to apply the knowledge gained to the understanding of the mechanisms of drug action and to acquire useful skills for future employment.To know how to communicate learned information and knowledge to experts and not experts.


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Course unit content

Molecular and cellular oncology

Full programme

Neoplasia. Definitions and nomenclature. Benign and malignant neoplasms. Grading and staging of tumors. Molecular basis of cancer. Oncogenic DNA and RNA virus. Protooncogenes, oncogenes and oncoproteins. Tumor suppressor genes. Survival and pro-apoptoticc genes. DNA repair genes. Molecular basis of multistep carcinogenesis. Angiogenesis. Tumor progression. Invasion and metastasis. Chemical carcinogenesis: initiation and promotion. Carcinogenic chemicals. Radiation carcinogenesis. Microbial carcinogenesis. Genetic predisposition to cancer. Effects of tumours on the host. Nutritional and hormonal effects. Biological basis of anti-neoplastic therapies. Study of biology, classification and therapy of breast, lung, colon cancer and melanoma.


Robbins e Cotran: Le Basi Patologiche delle Malattie. Elsevier VIII edizione.
Pontieri-Russo-Frati: Patologia Generale.Piccin IV edizione

Teaching methods

The topics in the program will be presented and discussed through lectures, with the aid of iconographic material, trying to involve the student so that it can be an active part of the lesson.

Assessment methods and criteria

The assessment of the achievement of the objectives of the course provides a written test. Through questions regarding the course content will be determined whether the student has achieved the goal of knowledge and understanding of the content and if he has reached the goal of applying the acquired knowledge.Multiple choice test (20 positive test /30).

Other information

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