This course provides an introduction to Medicinal Chemistry and is integrated with the other Medicinal Chemistry courses delivered in the following years.
The course aims at providing the students with the knowledge and understanding of the basic chemical and toxicological concepts of drugs, to be applied to the study of the classes of drugs presented during the course. The acquired knowledge and methodology allow the student to analyze, describe and discuss, with proper language, the most relevant aspects of drug structure and action.
Besides the knowledge on general aspects of drug activity, the student will learn in detail the most important drugs belonging to the therapeutic classes treated, with particular consideration for their name, molecular formula, mechanism of action, therapeutic application, metabolic fate and toxicity.
At the end of the course the student is expected to:
1. Understand how the structural, chemical and physicochemical properties of a drug affect its biological activity, metabolic transformation, adverse reactions and interaction with other drugs.
For the classes of drugs treated during the course: know the names, simple formulas, origin and application. Understand (recognize, explain and discuss) complex formulas, structure-activity relationships, chemical, physicochemical toxicological and metabolic properties of drugs (Knowledge and understanding).
2. For drugs treated and their structural analogs: go from formula to name and vice versa. Infer chemical and physicochemical properties of drugs and discuss how they can affect biological properties, including metabolism and toxicity. (Applying knowledge and understanding).
3. Draw consequences on the use of drugs based on their structural, chemical and physicochemical properties (Making judgements).
4. Report with proper language, to specialists and non-specialists, knowledge and concepts related to the classes of drugs treated during the course. Answer properly to questions, suggestions and criticisms (Communication skills).
5. Learn to infer general rules from examples. Learn to search and critically evaluate reliable sources of information and literature (Learning skills).