Learning objectives
SELECTED TOPICS of MEDICINAL CHEMISTRY:At the end of the teaching activity, the student must have acquired chemistry knowledge of the classes of drugs treated in the program and the most important concepts in medicinal chemistry. Details are described in the course Syllabus.
BIOTECHNOLOGICAL DRUGS: The main goal of the course is to provide basic information to know and understand the properties, application and problems related to the production, characterization and use of drugs of biotechnological origin.
The comprehensive introduction on methodologies for production, characterization and purification of protein therapeutics, and the description of their pharmacodynamic and pharmacokinetic properties, toxicity and immunogenicity will allow the student to apply his/her knowledge to the identification and evaluation of the relevant properties and issues related to each biotech drug.
Prerequisites
Students who intend to take Supplement to Pharmaceutical Chemistry/Biothecnological Drugs examination must have already taken Pharmaceutical and Toxicological Chemistry I and Pathology exams
Course unit content
This is an integrated teaching consisting of two modules, Selected Topics of Medicincal Chemistry and Biotechnological Drugs. The first module deals with the drugs used in the treatment of hyperlipoproteinemias, antithrombotic drugs, drugs of the endocrine system, drugs on inflammatory and immune responses.
The second module deals with the main biotechnological methodologies and the main classes of biotechnological drugs used in various therapeutic areas, including hormones, enzymes, cytokines, monoclonal antibodies.
Full programme
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Bibliography
Thomas L. Lemke, David A. Williams, Victoria F. Roche, S. William Zito: Foye's Principi di Chimica Farmaceutica, Piccin.
G.L. PATRICK: "Introduzione alla Chimica Farmaceutica", EdiSES.
WILSON & GISVOLD: "Chimica Farmaceutica", casa Editrice Ambrosiana.
Maria Luisa Calabrò, Compendio di Biotecnologie Farmaceutiche, EdiSES, Napoli, 2008.
Daan J.A. Crommelin, Robert D. Sindelar, Biotecnologie Farmaceutiche, Zanichelli, Bologna.
Daan J.A. Crommelin, Robert D. Sindelar, Bernd Meibohm, Pharmaceutical Biotechnology, Fourth Edition, Springer, 2013.
Teaching methods
Through oral lessons with slides will be presented and discussed matters relating to the course content.
Lectures are conducted with the aid of slides whose contents are available to students. The teaching material available online is not a replacement but a supplementary of reference texts, and a guide to a better understanding of the topics to be studied.
Assessment methods and criteria
The achievement of the objectives of the course is checked by oral examination. The markes obtained in the two modules will be mediated.
Other information
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