PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II
cod. 00133

Academic year 2017/18
4° year of course - Second semester
Professor
SILVA Claudia
Academic discipline
Chimica farmaceutica (CHIM/08)
Field
Discipline chimiche, farmaceutiche e tecnologiche
Type of training activity
Characterising
72 hours
of face-to-face activities
9 credits
hub: PARMA
course unit
in ITALIAN

Learning objectives


At the end of the teaching activity, the student should have gained chemistry knowledge and expertise in pharmacological therapy associated with the various pathologies treated in the program and mastered the most important concepts that characterize the medicinal chemistry. In particular, the student should be able to: - Understand the chemical characteristics of the drugs included in the therapeutic classes treated in the program, their uses, biological activity and toxicity, the relationship between the chemical structure and biological activity, the interaction with the biological substrate, the chemical-physical and metabolic aspects (Knowledge and understanding). - Apply his knowledge of the drug's action and pharmacological profile, understand the physical chemistry and the metabolic aspects and their influence on pharmacological activity, identify the structural features important for the drug action, use a proper nomenclature according to international rules (Ability to apply knowledge and understanding). - Expose concepts in a clear and straightforward way and through a formally correct language, be able to interact with people with scientific training in different areas. (Communication Skills) - Know how to evaluate the relevance of the different therapeutic classes treated in the pathologies considered (making judgments). - Link the different topics dealt with each other and with basic and related disciplines (Learning Skills).

Prerequisites


Knowledge of organic chemistry, biochemistry, physiology, pharmacology.

Course unit content


Drugs acting on the central an peripheral nervous system and drugs acting on the cardiovascular system.

Full programme


Drugs acting on the nervous system. Principal neurotransmitters of the Nervous System. -Depressors of the Nervous System: General anesthetics: intravenously and by inhalation. Hypno-sedatives. Analgesic narcotic: natural prototypes, derived synthesis and semi-synthesis. Anticonvulsants. Antiparkinson. Muscle relaxants. Anxiolytics. Neuroleptics. Local anesthetics. -Nervous System Stimulants: central analeptic. Psychostimulants. MAO inhibitors. Anorectic. Antidepressants. Hallucinogens. Drugs of the sympathetic nervous system and parasympathetic nervous system. Cardiovascular Drugs: Drugs heart: cardiac glycosides, antiarrhythmics and antianginal. ACE inhibitors, calcium channel blockers. Central and peripheral vasodilators. Antithrombotic, thrombolytic agents, coagulants and substitutes emoplasmatici. Diuretics. Antacids and inhibitors of gastric acid secretion.

Bibliography


W.O. FOYE: “Principi di Chimica Farmaceutica”, Piccin. G.L. PATRICK: "Introduzione alla Chimica Farmaceutica", EdiSES. WILSON & GISVOLD: "Chimica Farmaceutica", Casa Editrice Ambrosiana

Teaching methods


Through oral lessons will be presented and discussed matters relating to the course content.

Assessment methods and criteria


The assessment of the achievement of the course's objectives is done through oral examination. Two topics are submitted to the student. It will first be assessed if the student has achieved the first objective of knowledge and understanding of the topics discussed. Questions are then asked to allow the student to connect the different parts of the teaching, to interpret the pharmacological profile of the drugs, to discuss the relationship between the structure and the biological activity and the pharmacokinetic properties. This is the minimum level for the exam to be sufficient. It also assesses the student's ability to communicate knowledge and skills in verbal form through the use of a proper language of the discipline.

Other information


Lectures are conducted with the aid of slides whose contents are available to students. The teaching material available online is not a replacement but a supplementary of reference texts, and a guide to a better understanding of the topics to be studied.