The Course “Histology of Human Tissues and Biology and Clinical Applications of Stem Cells”, abbreviated ITUBACCS ("Istologia dei Tessuti Umani, Biologia e Applicazioni Cliniche delle Cellule Staminali"), represents a unique and highly innovative Course within the Italian University System. It is an interactive Course open to students of the second level of education, or higher, and is characterized by an integration of functional histology and the biology of stem cells. While solidly dwelling upon the fundamentals of the structure and organization of human tissues, the Course aims at imparting notions about the functional and molecular bases for the architecture, maintenance and remodeling of tissues and how this is assured by the purporting of the stem/progenitor cells residing in specific niches. The Course has therefore the objective to allow students to acquire a comprehensive view of how homeostasis of human tissues is controlled by a delicate balance between a precise arrangement of their cellular and extracellular matrix elements and the regeneration capabilities that the endogenous progenitor/stem cells may possess. Ultimately, the student is expected to gain a global understanding of the intimate association between tissue structure (morphology) and homeostatic dynamics (function).