HUMAN AND MODEL ORGANISMS MOLECULAR GENETICS GENOTOXICITY
cod. 1001176

Academic year 2012/13
1° year of course - First semester
Professor
Academic discipline
Genetica (BIO/18)
Field
Discipline biologiche
Type of training activity
Characterising
72 hours
of face-to-face activities
9 credits
hub: PARMA
course unit
in - - -

Learning objectives

Aims of the course is the study of genetic approaches applied to genomics and functional analysis in microorganisms. Particular attentions will be paied to model organisms in fundamental and biotechnologic applications.

Prerequisites

None

Course unit content

YEAST AS MODEL ORGANISM
Forward e reverse genetics- Genome sequencing in S. cerevisiae- Comparative genomics in yeasts- S. cerevisiae deletant collection and use of null mutants in functional analysis- Methods for gene interaction studies applied to human diseases - Yest as model organism for the study of mitochondrial genetics- Yeast as model organism for the study of mitochondrial diseases.

FUNCTIONAL ANALYSIS IN PLANTS

Caenorhabditis elegans AS MODEL ORGANISM
Forward e reverse genetics in C. elegans. Functional analysis by RNAi - C. elegans as model organism for the study of human pathologies.
Drosophila melanogaster AS MODEL ORGANISM
Forward e reverse genetics in D. melanogaster. - D. melanogaster as model organism for the study of human pathologies.

HUMAN GENETICS. HUMAN GENETIC DISEASES.

PHARMACOGENETICS. GENE THERAPY.

Full programme

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Bibliography

P. Meneely
Analisi Genetica Avanzata
Ed. McGraw-Hill

Original papers selected by the teacher

E.H.McCONKEY – Genetica Umana. Una prospettiva molecolare – Zanichelli

Teaching methods

frontal lectures and exercises

Assessment methods and criteria

Tests during the course and final oral examination

Other information

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