Learning objectives
Knowledge and understanding of pharmacokinetics and pharmacodynamics fundamentals
Prerequisites
Knowledge of basic disciplines (anatomy, physiology, istologybichemistry, general pathology).
Full programme
General pharmacology, cellular and molecular. pharmacology. Branches of pharmacology. Concept of drug,
Drug development: preclinical phase with toxicological tests, clinical Phases, pharmacovigilance.
Pharmacokinetics: absorption, distribution, biotransformation and elimination of drugs; clearance; half-life; bioavailability; pharamceutical forms and routes of drug administration.
Pharmacodynamics: mechanisms of action of drugs; Drug-receptor interaction; affinity, potency, efficiency; Drugs acting as agonists and/or antagonists; dose-response curve. Drugs acting at ion channels, carriers, DNA. Enzyme inhibitors.
Principles of interaction between drugs.
Modification of the response to drugs: tachyphylaxis, tolerance, drug resistance. Pharmacogenetics and idiosyncratic responses.
Drug toxicity.
Bibliography
Rang, Dale et al., Pharmacology - Elsevier;
Katzung: Pharmacology (last ed.);
Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)
Assessment methods and criteria
Oral exam (after the second part of the course)