Learning objectives
The course aims to provide students with basic notions of Inorganic Pharmaceuticals. Provide the students with theoretical and applicative notions on multidimensional NMR, with attention on paramagnetic, inorganic and bioinorganic systems.
Prerequisites
- - -
Course unit content
Metals in medicine: a historical perspective. General requirements, structure-activity relationships. Target of metalloparmaceuticals and reactions of metal complexes in biological systems. Diagnostics: the role of metals in the anatomical and functional imaging. Human therapy: Chelation; metal complexes in cancer therapy (compounds of platinum). Radiopharmaceutical therapy.
Monodimensional NMR spectroscopy. FT-NMR. Relaxation rates and their determination. Correlation time. Multidimensional NMR. COSY, TOCSY, HETCOR E HMQC spectra. Nuclear Overhauser Effect. NOESY spectra. Elements on analysis of parameters obtained by multidimensional NMR. Elements of n-dimensional experiments. NMR spectra of paramagnetic compounds. Elements on analysis of parameters obtained by NMR spectra of paramagnetic compounds of bioinorganic interest. Eteronuclear NMR. Characterization of compounds in the solid state. X-ray diffraction techniques.
Full programme
- - -
Bibliography
Chris Jones, John Thornback, Medicinal Applications of Coordination Chemistry, RSC Publishing, 2007
J. Keeler, Understanding NMR spectroscopy, John Wiley and Sons, 2005
Teaching methods
Oral lessons
Assessment methods and criteria
Written examination
Other information
- - -
