Learning objectives
To bring mechanisms and nature of toxic effects of drugs and xenobiotics to student's knowledge.
Prerequisites
It is necessary to pass the Pharmacology examination.
Course unit content
General part
-First principles of toxicity
-Experimental toxicology, evaluation of toxicological risks, mechanisms and tests of toxicity
-ADME of toxic substance
-Metabolism of xenobiotics
-Cancerogenesis, teratogenesis and mutagenesis
-Idiosincrasic and allergic reactions. Interactions between xenobiotics
Special part
-Metals, Solvents, Pesticides, IPA, PCOD, PCB
-Enviromental toxicoogy
-Alimentary toxicology
-Occupational toxicology
-Toxicology of biotecnological products
- Poisons and antidotes
Toxicology of:
-Lung
-Kidney
-Liver
-Cardiovascular Sistem
-Central Nervous Sistem (CNS)
Full programme
General Section
· General principles of toxicology.
· Mechanisms of toxicity. Toxicity test.
· Absorption, distribution and excretion of toxic substances.
· Biotransformation of xenobiotics.
· Carcinogenesis, teratogenesis, mutagenesis.
special section
· Experimental toxicology and toxicological risk assessment.
· Idiosyncratic reactions and allergic diseases, interactions between xenobiotics.
· Toxicology of pesticides, metals, solvents, pesticides, PAHs, PCOD, PCB, plant and animal toxins.
· Environmental Toxicology: air pollution, water and soil.
· Toxicology food and nutrition: Food Additives and Contaminants. Regulatory bodies.
· Occupational Toxicology
· Toxicology of biotechnology products.
· Toxicology of principal organs.
Bibliography
-ERNEST HODGSON: “Tossicologia Moderna”, EdiSES
-CASARETT & DOULL’S: "Tossicologia: fondamenti dell’azione delle sostanze tossiche", Ed. EMSI,
Roma.
-W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.
-C.L. GALLI, E. CORSINI, M. MARINOVICH “Tossicologia”, Piccin
Teaching methods
Traditional lesson
Assessment methods and criteria
Oral examination
Other information
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