Learning objectives
The course of Medicinal Chemistry II provides chemical informations about the pharmaceutical classes included in the programme, with special regard to the relationships between chemical structure and pharmaceutical, pharmacodynamic and pharmacokinetic properties. Moreover, the pourpose of the course is the study of the chemical and physicochemical properties of the drugs, the mechanism of action, the most important biotransformations and metabolic considerations, the classification of the drugs and the nomenclature.
Prerequisites
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Course unit content
Neurotransmmitters of the Nervous System.
Drugs acting on the Central Nervous System: CNS Depressors and CNS Stimulants. Local anestetics.
Agents for control of gastric acidity.
Antineoplastic agents.
Antiviral agents.
Full programme
Drugs acting on the Central Nervous System
Neurotransmmitters of the Nervous System
CNS Depressors:
General anesthetics
Sedative-Hypnotics
Narcotic analgesics
Drugs effective in the therapy of the epilepsies
Drugs effective for Parkinson's disease
Spasmolytic agents
Anxiolytic agents
Antipsychotic agents
Local anestetics
CNS Stimulants:
Analeptics
Psycoanaleptics and MAO-inhibitors
Anti-obesity drugs
Antidepressants
Hallucinogens.
Agents for control of gastric acidity.
Antineoplastic agents:
Alkylating agents
Antimetabolites
Antimitotic drugs
Antibiotics
Topoisomerase inhibitors
Ormones and antagonists.
Antiviral agents:
Tiosemicarbazones and cyclic amines
Phosphonates
Nucleosides and acyclic nucleosides
Neuroaminidase inhibitors
Antiherpesvirus agents
Antiretroviral agents and protease inhibitors
Bibliography
W.O. FOYE: “Principi di Chimica Farmaceutica”, Piccin.
G.L. PATRICK: "Introduzione alla Chimica Farmaceutica", EdiSES.
D.J. ABRAHAM: “Burger’s Medicinal Chemistry and Drug Discovery”, Wiley, New York.
Teaching methods
Oral lesson
Assessment methods and criteria
Oral exam
Other information
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